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Author Archive for: 3wmedia
Entries by 3wmedia
Automation and integration of LC-MS/MS services into the clinical laboratory workflow
Despite significant inherent advantages of liquid chromatography-tandem mass spectrometry (LC-MS/MS) over immunoassay techniques in clinical laboratory applications, its adoption into routine practice has been slower than might have been expected. The barriers to more widespread uptake are a function of issues in the laboratory workflow. This article analyses those issues and discusses how they can […]
Inflammation: a newly identified risk of depression?
According to the World Health Organization, depression affects more than 300 million people and is the leading cause of ill health and disability worldwide. Currently, diagnosis of depression involves the use of questionnaires about the patient’s general health, the way they are feeling and how this is affecting them. Blood tests are carried out during […]
Flow cytometry and immunophenotyping for chronic lymphoproliferative disorders
Modern hematology emphasizes a multiparametric diagnostic approach and the basic parameters, beside history of the disease and clinical examination, are morphological, immunophenotypic and genetic evaluation. Flow cytometry plays an important role in diagnosis of a large group of hematological diseases. This article reviews the basic principles of flow cytometry and its use in hematology diagnosis, […]
Establishing flow cytometry as a primary diagnostic method for the investigation of suspected platelet function disorders
Although considerable progress has been made in our understanding of the role of platelets in hemostasis, the analytical methods clinically available for investigating platelet function defects remain limited. Herein, we describe an initiative at Linköping University Hospital, Sweden, to use flow cytometry for measuring platelet function in patients with a suspected bleeding disorder. by Dr […]
Ber-EP4 (CD326) testing by flow cytometry: a rationalized algorithm-based approach
Flow cytometry has traditionally been used to identify hemato-lymphoid neoplasms. However, the flow cytometry laboratories that deal with tissues would often receive samples that have an epithelial neoplasm. In our laboratory, we use flow cytometry to identify cells with epithelial differentiation using Ber-EP4 antibody that targets CD326 (EpCAM). We have formulated an algorithm-based approach for […]
Biochemical investigation of monoclonal gammopathies
Monoclonal gammopathy (MG) refers to the presence of monoclonal immunoglobulin produced by clonally expanded plasma cells or immunoglobulin-expressing lymphocytes. MG is a key feature of a wide spectrum of diseases ranging from the indolent MG of undetermined significance to the overt multiple myeloma. In this article, we discuss the utility and pitfalls of common biochemical […]