Vitamin D status is currently assessed by measurements of total 25-hydroxyvitamin D [25(OH)D]. However, over 99% of circulating 25(OH)D is bound to protein, vitamin D binding protein in particular. The free hormone hypothesis stipulates that only the free form crosses the cell membrane to exert biologic action. Measurement of free 25(OH)D is now available. by […]
The 24,25-dihydroxyvitamin D [24,25(OH)2D] is a catabolite of 25-hydroxyvitamin D [25(OH)D]. This transformation is performed by 1,25-hydroxyvitamin D 24-hydroxylase (or 24-hydroxylase, encoded by the CYP24A1 gene). Mutations in CYP24A1 can lead to severe diseases such as idiopathic infantile hypercalcemia (IIH). Explorations of hypercalcemia with suppressed parathyroid hormone levels and normal or high phosphatemia should now […]
CTC-derived AR-V7 detection as a prognostic and predictive biomarker in advanced prostate cancerBastos DA, Antonarakis ES. Expert Rev Mol Diagn 2018; 18(2): 155–163 Prostate cancer is a highly heterogeneous disease, with remarkably different prognosis across all stages. Increased circulating tumour cell (CTC) count (≥5) using the CellSearch assay has been identified as one of the […]
The second edition of the Greiner Bio-One customer magazine bioLOGICAL is now available on their website. Interesting articles about capillary blood sampling are included in this issue. In the article by Jasna Lenicek Krleza, PhD, the reader will learn about which factors to pay special attention to in capillary blood collection to get high-quality samples. […]
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