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Author Archive for: 3wmedia
Entries by 3wmedia
Molecular Diagnostics Literature Review
Genome-wide analysis of circulating cell-free DNA copy number detects active melanoma and predicts survivalSilva S, Danson S, Teare D, Taylor F, Bradford J, et al. Clin Chem 2018; 64(9): 1338–1346. BACKGROUND: A substantial number of melanoma patients develop local or metastatic recurrence, and early detection of these is vital to maximize benefit from new therapies […]
Placental growth factor testing reduces time to diagnosis for women with suspected pre-eclampsia
Pre-eclampsia is a condition that affects approximately 2–8% pregnancies worldwide and, although the cause is not really understood, is thought to be due to poor function of the placenta. Early signs that create suspicion of pre-eclampsia in the mother typically include hypertension, proteinuria and edema (particularly of the pitting type) of the ankles. Symptoms of […]
Detection and typing of HPV for cervical cancer prevention according to Meijer criteria
HPV testing is a linchpin of cervical cancer prevention, providing an effective alternative to the long-standing Pap test. The HPV analysis should encompass all relevant anogenital HPV types and differentiate between high-risk types, which can induce cancer, and low-risk types, which cause benign genital warts. It is also critical to identify multiple and persistent infections, […]
Implementing digital blood cell analysis technology in a distributed laboratory network
The recent introduction of the CellaVision DC-1 makes it possible for small labs to implement the same digital methodology for performing blood cell differentials that is commonly used by large laboratory organizations. CellaVision recently teamed up with Alberta Public Laboratories (APL) to conduct an in-situ product evaluation assessing the utility and impact of CellaVision DC-1 […]
Using whole-genome sequencing to predict antimicrobial resistance
Thousands of strain-specific whole-genome sequences are now available for a wide range of pathogenic bacteria. Using these data, approaches based on machine learning can now be used to predict the results of antimicrobial susceptibility tests from sequence alone. Recent studies have demonstrated the ability to predict minimum inhibitory concentrations with accuracies up to 95 %. Employing […]
Activated partial thromboplastin time assay
The activated partial thromboplastin time coagulation assay is one of the most frequently performed tests in hematology, and has a variety of uses in clinical practice. Accurate interpretation of the test depends on both clinical context (i.e. why the test was ordered) as well as an understanding of each laboratory’s normal reference range and assay […]
Novel strategies for clinical coagulation diagnostics and therapy monitoring
Clinical coagulation assays are an important part of anticoagulation measurements and monitoring. Despite the rise of new promising technologies, traditional coagulation assays were largely unchanged in the last decades. Here we discuss the application of microfluidics and nanotechnology to clinical coagulation diagnostics and anticoagulation therapy monitoring. by Dr Francesco Padovani and Prof. Martin Hegner IntroductionFast, […]