Parasitology: An Integrated Approach Ed. by Alan Gunn and Sarah Jane Pitt, Pub. by Wiley-Blackwell 2012, 456 pp, €41.80 This book provides a concise, student-friendly account of parasites and parasite relationships that is supported by case studies and suggestions for student projects. The book focuses strongly on parasite interactions with other pathogens and in particular […]
According to applied physiologist Dr Brian Moore, and Dr Andrew Hodgson, Consultant Physician (Haematology) – co-founders of the Irish company ORRECO – one of the most difficult elements of competing in sport at a world class level is to balance training hard whilst ensuring adequate recovery. Dr Moore and his integrated team of high performance […]
The cardiorenal syndrome (CRS) involves both kidney failure and heart failure, with the failing organ initially being either the heart or the kidney; usually one failing organ leads to the failure of the other. While use of biomarkers and imaging techniques can assess cardiovascular function, the assessment of renal injury and function is complex in […]
Although significant progress has been made to improve blood safety and efficiency, laboratories still face workforce challenges, and the lack of global standards and better quality controls in blood management and haemovigilance pose a threat to patient safety. To help address these challenges, a symposium was hosted at the 2011 American Association of Blood […]
We have investigated the effects of three (Lepirudin, Argatroban and Bivalirudin) direct thrombin inhibitors (DTI) on routine and dedicated assays. We found routine tests to be non-discriminative between concentrations of different DTI. The dedicated Hemoclot assay showed identical lineair increases for all three DTI. We conclude that a dedicated calibrated assay based on a diluted […]
There are a huge number of peer-reviewed papers covering sepsis, and it is frequently difficult for healthcare professionals to keep up with the literature. As a special service to our readers, CLI presents a few key abstracts from the clinical and scientific literature chosen by our editorial board as being particularly worthy of attention. Predictors […]
Sepsis frequently results in acute kidney injury (AKI). Although AKI markedly contributes to mortality in sepsis, its diagnosis is frequently delayed due to limitations of current biomarkers of renal impairment. Neutrophil-gelatinase-associated lipocalin (NGAL) has been demonstrated to be a biomarker of early AKI. This review analyses the potential use of NGAL in sepsis. by Dr […]
Early detection to enable timely therapeutic intervention is crucial for improved outcome in patients with sepsis, but diagnosis is difficult, as the clinical signs associated with the condition commonly occur in patients with systemic inflammatory response syndrome (including sterile SIRS). This article discusses the current and emerging PCR-based technologies for the diagnosis of sepsis. by […]
At the end of the 19th century the Scottish pathologist William Russell published an article in The Lancet titled ‘The Parasite of Cancer’ [The Lancet 1899; 3984: 1138-1141]. The response by the physicians of the day ranged from scepticism to sheer disbelief, largely because cancer is considered to be a non-communicable disease. With the exception […]
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