Thiopurine methyltransferase: a paradigm of pharmacogenetics
Thiopurine methyltransferase (TPMT) is an enzyme involved in the metabolism of thiopurine drugs such as azathioprine. TPMT genotyping or measurement of enzyme activity prior to treatment enables prediction of those individuals most at risk of myelotoxicity in whom these drugs should be avoided or used in reduced doses. by Dr Joshua Ryan, Christiaan Sies and […]
