While any tissue can be targeted using the patented technology, TherageniX will focus orthopaedic applications first. It will combine autologous bone marrow cells from the patient with its platform technology to drive the production of genes, such as BMP for osteogenesis, helping to improve the regenerative capacity of skin, bone, muscle, and cartilage following surgery.
The transplantation of autologous bone is the gold standard bone repair strategy. However, this process has drawbacks and bone implants may fail due to poor integration or infection at the harvest site, or do not provide satisfactory functionality. This can result in delayed recovery, re-operation, poor quality of life and increased costs. TherageniX’s novel gene therapy technology improves upon these bone-grafting procedures, utilizing the body’s cellular machinery to enhance regeneration at the surgical site. The technology easily integrates with established surgical procedures, and rapid transfection of patient’s cells means no additional time is required in the operating theatre. It offers a simple and cost-effective solution to help improve regeneration, leading to better functional outcomes for patients.
Dr Anandkumar Nandakumar, CEO of TherageniX, commented: “Our mission is to advance treatments in repairing tissue damage and we are grateful for the support from Innovate UK at this early stage. This grant is testament to the potential of TherageniX’s novel approach to tissue regeneration and will enable us to make great strides in manufacturing our powdered gene therapy.