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AMSBIO’s CollaFibR scaffolds set new benchmark for 2D and 3D cell culture applications

Produced using a patented dry-spinning technology – CollaFibR from AMSBIO is a highly consistent collagen fibre matrix that closely mimics the biomechanical and biochemical properties of natural collagen scaffolds, offering an accurate representation of in-vivo conditions.

These innovative collagen fibres are seamlessly produced on a commercial scale using an automated state-of-the-art Good Manufacturing Process (GMP), catering to a variety of applications in 3D cell culture and tissue engineering.

Offered as a user-friendly 12-well plate insert, CollaFibR scaffolds are perfect for creating physiologically relevant environments for 2D and 3D cell culture applications by inducing cellular alignment, migration, and elongation. AMSBIO can also offer custom CollaFibR scaffolds tailored to meet specific needs, as the automated manufacturing process enables the thicknesses, porosities, and alignment of the scaffolds to be controlled with a high batch-to-batch consistency and high cell viability.

Available with a fluorescent tag, CollaFibR scaffolds are fully compatible with brightfield, epifluorescence, confocal and live cell microscopy. Supplied UV sterilized and ready-to-use, CollaFibR scaffolds are degradable with collagenase enabling quick and easy cell extraction.

CollaFiBR is also available as short dry spun 50 μm collagen fibres that can be used as an additive for bioinks and hydrogels. These GMP fibres increase the cellular viability, shape fidelity and biological relevance of bioprinted constructs.

Setting a new benchmark for cell culture consistency, CollaFibR scaffolds are enabling exciting innovation in applications such as 3D tissue culture, myelination studies and contract tissue engineering.

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Primary tenocytes (red tomato) grown in CollaFibR scaffold, stained with anti-collagen (green)

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CollaFibR scaffold in 12-well plate format