Featured Articles

Deep quantitative glycoprofiling: new method for fast, sensitive and in-depth mass spectrometry of protein glycosylation

, 19 March 2025/in Protein Analysis, Proteomics & Mass Spectrometry, Featured Articles /by panglobal

What is protein glycosylation? There are several types of post-translational modifications (PTMs) that proteins can undergo. Phosphorylation, methylation and acetylation all involve the addition of small chemical groups which affect function. Ubiquitylation involves the addition of the small peptide, ubiquitin, which targets proteins for degradation. Glycosylation is one of the more complex forms of PTM, […]

Prognostic value of circulating biomarkers in men compared to women presenting with acute chest pain

, 19 March 2025/in Featured Articles, Cardiac Biomarkers /by panglobal

by Dr Gard Myrmel We have known for a while now that the symptoms of acute coronary syndromes can be different for women compared to men. Here, Dr Myrmel discusses how the differences between the sexes also extend to the prognostic value of circulating biomarkers in patients presenting with acute chest pain.

Macrotroponin: potential source of cardiac troponin assay interference

, 18 March 2025/in Cardiac Biomarkers, Featured Articles /by panglobal

by PD Dr Angelika Hammerer-Lercher Measurement of cardiac-specific troponin I or T forms is part of the diagnostic pathway to rule in or rule out acute coronary syndromes, such as heart attack, as well as for prognostication of future cardiovascular disease. CLI chatted to Dr Angelika Hammerer-Lercher (Chief Physician and Director of Central Medical Laboratories, […]

Impact of glycosylation on NT-proBNP immunoassay performance

, 16 March 2025/in Featured Articles, Cardiac Biomarkers /by panglobal

by Dr Aleksandra Havelka Assays for NT-proBNP form a key part of diagnosing/ruling out, predicting and managing heart failure. CLI chatted to Dr Aleksandra Havelka (Gentian Diagnostics) to find out more about the challenges and limitations of measuring NT-proBNP concentrations, particularly the effects of glycosylation, and what developments are on the horizon to overcome these […]

Laboratory diagnosis of Pneumocystis jirovecii pneumonia

, 14 March 2025/in Featured Articles, Microbiology /by panglobal

by Dr Osaretin Emmanuel Asowata The detection of Pneumocystis jirovecii in immunocompromised patients is crucial for the treatment of Pneumocystis jirovecii pneumonia (PCP) and to prevent invasive infection. However, PCP can be challenging to diagnose clinically, as symptoms are non-specific. There are several laboratory methods that can be used to diagnose PCP and their advantages […]

Flow cytometry technique identifies disease and therapy-associated microbial signatures in Crohn’s disease

, 23 January 2025/in Gastrointestinal Disorders, Featured Articles /by panglobal

Background Recent research suggests that the incidence of inflammatory bowel disease (IBD) in the UK is 1 in every 123 people, and that previously these numbers have been largely underestimated.

Reducing KAT7 expression inhibits colorectal cancer progression

, 23 January 2025/in Gastrointestinal Disorders, Featured Articles /by panglobal

Colorectal cancer background and risk factors Colorectal (or bowel) cancer (CRC) is cancer anywhere in the colon (the large intestine) or the rectum.

Diagnosis and management of subarachnoid hemorrhage

, 23 January 2025/in Featured Articles, Microscopy & Imaging /by panglobal

If a patient has a suspected subarachnoid brain hemorrhage (SAH), time is of the essence. CLI chatted to Dr Suneesh Thilak (New Cross Hospital, Wolverhampton, UK) to find out about the role that imaging plays in diagnosis, securement and subsequent patient management of SAH.

Technological advances allow use of mid-infrared spectroscopy for therapeutic drug monitoring

, 23 January 2025/in Featured Articles, Therapeutic Drug Monitoring /by panglobal

Therapeutic drug monitoring is used for a number of reasons. The usual techniques include immunoassay and mass spectrometry, both of which have limitations. CLI chatted to Dr Pin Dong (University of York, York, UK) to discuss the potential for Fourier transform infrared spectroscopy to bridge the gap and provide high specificity measurements with a fast […]

Novel customizable immunoassay platform promises rapid, sensitive disease detection without complex laboratory requirements

, 8 November 2024/in Autoimmunity & Allergy, Featured Articles /by panglobal

A groundbreaking customizable immunoassay system developed by Japanese researchers offers rapid detection of disease biomarkers, allergens and other biomolecules with exceptional sensitivity, potentially revolutionising point-of-care diagnostics

Deep quantitative glycoprofiling: new method for fast, sensitive and in-depth mass spectrometry of protein glycosylation

Prognostic value of circulating biomarkers in men compared to women presenting with acute chest pain

Macrotroponin: potential source of cardiac troponin assay interference

Impact of glycosylation on NT-proBNP immunoassay performance

Laboratory diagnosis of Pneumocystis jirovecii pneumonia

Flow cytometry technique identifies disease and therapy-associated microbial signatures in Crohn’s disease

Reducing KAT7 expression inhibits colorectal cancer progression

Diagnosis and management of subarachnoid hemorrhage

Technological advances allow use of mid-infrared spectroscopy for therapeutic drug monitoring

Novel customizable immunoassay platform promises rapid, sensitive disease detection without complex laboratory requirements

Latest issue of Clinical laboratory

Deep quantitative glycoprofiling: new method for fast, sensitive and in-depth mass spectrometry of protein glycosylation

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bit.bio introduces ioTracker cells

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