Aggregating clinical use and purposeful laboratory monitoring By Nicholas Armfield Ketamine is gaining attention as an analgesic, antidepressant and as a treatment for refractory status epilepticus. Ongoing support from the clinical laboratory is improving patient monitoring and increasing our understanding of ketamine as a clinical therapeutic. Low-dose intravenous and a relative high volume of distribution […]
by Dr Roopa Rao and Arden Shen The incidence of heart failure (HF) is increasing globally. Biomarkers in HF play a key role in diagnosis and prognostication. Ideal biomarkers should be easily measurable with distinct values in normal physiology, disease state and be a marker of therapeutic intervention. Several biomarkers have emerged that are potentially […]
By Dr Kyle H. Cichos and Dr Wilhelm Paulander This review examines periprosthetic joint infection (PJI) detection, highlighting the limitations of traditional methods and introducing isothermal microcalorimetry (IMC) as an innovative tool. IMC offers rapid, sensitive PJI detection, overcoming the challenges of culture-based and molecular diagnostics. Its potential applications in real-time monitoring, treatment efficacy, and […]
By Dr Seul Kee Byeon and Dr Akhilesh Pandey An elevated ratio of monolysocardiolipin to cardiolipin is a hallmark feature of Barth syndrome, a genetic disorder caused by mutations in the TAFAZZIN gene. Liquid chromatography-tandem mass spectrometry can be used as a clinical laboratory test to calculate the ratios of monolysocardiolipins to cardiolipin species for […]
Endometriosis is an incurable, chronic condition, associated with debilitating pain and reduced fertility. It is thought to affect 190 million women worldwide and is associated with huge costs to the economy though loss of earnings and cost of health-care/treatment. Currently, diagnosis on average takes around 8 years. CLI chatted to Dr Barbara Guinn (Centre for […]
Getting the most from every drop – new advances in blood separation Alexandra Sommer, Senior Product Manager, Clinical Diagnostics at Tecan
By Kellie Madigan The quality and consistency of immunostaining contributes highly to productivity for pathologists and cellular pathology laboratory managers. An evaluation study among key opinion-leaders in this area of healthcare has sought to understand how today’s pathologists perceive staining quality, its impact on their working life, and what the term ‘quality’ covers. This article […]
Running clinical lab tests is a labour-intensive business. Even if the actual test is done by an automated platform, many stages still require manual handling of the specimens, which can limit throughput and allow the potential for errors to occur (we’re only human, after all!). Increasing the amount of automation circumvent these limitations and CLI […]
By Serena Shell, Bheemraj Ramoo, C. Clinton Frazee III and Prof. Uttam Garg Mycophenolic acid is an immunosuppressant administered to patients undergoing various organ transplants. Therapeutic drug monitoring of mycophenolic acid is important to reduce drug toxicity and organ rejection. This is accomplished using several techniques including immunoassays, high-performance liquid chromatography with an ultraviolet detector […]
By Dr Laura M. Labay and Dr Sherri L. Kacinko The forever contaminants of our generation PFAS (perfluoroalkyl and polyfluoroalkyl substances) are synthetic chemicals that have a wide range of industrial and manufacturing applications because of their chemical and thermal stability and their hydrophobic and lipophobic characteristics. PFAS are persistent in the environment, bioaccumulate in […]
August 2024
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