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Archive for category: Featured Articles

Featured Articles

Figure 1. Respondents gained a variety of INTEGRA pipetting solutions during the pandemic to handle high sample numbers

Responding to a global health crisis: the evolution of the lab

, 26 May 2023/in Featured Articles /by panglobal

by Dr Éva Mészáros Responding to a global health crisis: the evolution of the lab The COVID-19 pandemic forced life sciences laboratories all over the world to suddenly begin high volume PCR testing, to help gain the upper hand over this deadly disease. Many facilities had to adopt new pipetting platforms at short notice to […]

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https://clinlabint.com/wp-content/uploads/sites/2/2023/05/Graph-00.jpg 451 900 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2023-05-26 07:40:382023-05-26 08:16:29Responding to a global health crisis: the evolution of the lab
Four saliva samples containing SARS-CoV-2 RNA were mixed with target-specific capture oligonucleotides attached to magnetic beads. The solutions were heated to 95°C for 1 minute, then placed in a rack with a magnet. After 3 minutes the supernatants were replaced with a 1-step RT-qPCR master mix and subjected to a rapid cycling protocol (1 second at 95°C/1 second at 65°C). The same concentration of four pure RNA samples were amplified at the same time and acted as positive controls. the RNA extracted from saliva recorded the same quantification cycles (blue) as the untreated control RNA (red).

Remodelling qPCR as a tool for molecular diagnostics

, 26 May 2023/in Featured Articles /by panglobal

by Professor Stephen Bustin   Remodelling qPCR as a tool for molecular diagnostics PCR is an incredibly powerful tool in the field of molecular diagnostics, and its current role is embedded in the clinical laboratory where it is indispensable for non-time-critical routine testing. However, point-of-care testing via lateral flow devices, as seen in the recent […]

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https://clinlabint.com/wp-content/uploads/sites/2/2023/05/Fig-3.jpeg 768 1024 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2023-05-26 07:22:492023-05-26 08:20:09Remodelling qPCR as a tool for molecular diagnostics
Safety of blood and plasma products from pathogen transmission

Safety of blood and plasma products from pathogen transmission

, 25 May 2023/in Featured Articles /by panglobal

‘The Expert Report to the Infected Blood Inquiry: Statistics’ (http://bitly.ws/EAng) found that around 3650 people with bleeding disorders in the UK were infected with HIV or hepatitis viruses through the use of contaminated blood products. In addition, many people (8120) were found to be chronically infected with hepatitis C 10 years or more after receiving […]

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https://clinlabint.com/wp-content/uploads/sites/2/2023/05/Employees-working-in-the-Plasma-Purification-Area.jpg 1281 1920 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2023-05-25 15:11:352023-05-25 15:11:35Safety of blood and plasma products from pathogen transmission
David Kaye

Insight into clinical sample and consent tracking

, 23 March 2023/in Featured Articles /by panglobal

Clinical specimens, clinical trial samples and the information associated with them are precious resources that require careful curation. CLI caught up with David Kaye [Vice President and General Manager of BioFortis (a Q2 Solutions company)] to find out more about what this entails.

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https://clinlabint.com/wp-content/uploads/sites/2/2023/03/David-Kaye.jpg 1749 1619 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2023-03-23 13:12:232023-03-23 13:13:52Insight into clinical sample and consent tracking
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Detection of intrathecal antibody synthesis in CNS diseases

, 23 March 2023/in Featured Articles /by panglobal

The investigation of antibodies against pathogenic agents in cerebrospinal fluid (CSF) samples is part of the diagnostic work up in acute or chronic inflammatory processes of the central nervous system. This article describes the analysis of intrathecally produced antibodies in CSF and the interpretation of the results.

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https://clinlabint.com/wp-content/uploads/sites/2/2023/03/pxx_408604744-scaled-e1680865493293.jpg 612 900 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2023-03-23 13:00:042023-03-23 13:00:04Detection of intrathecal antibody synthesis in CNS diseases
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How should microbiology laboratories be prepared for the next unknown?

, 23 March 2023/in Featured Articles /by panglobal

What we learned from the last pandemic, which no one saw coming, is that it is difficult to answer the question “How should microbiology laboratories be prepared for the next unknown?” However, the last pandemic also taught us that it is imperative to try to answer such a question. In this article we will try […]

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https://clinlabint.com/wp-content/uploads/sites/2/2023/03/shutterstock_1978765637-scaled.jpg 2560 2551 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2023-03-23 12:42:562023-03-23 13:01:26How should microbiology laboratories be prepared for the next unknown?
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Minimizing the number of false positives in dexamethasone suppression testing for the diagnosis of Cushing’s syndrome

, 23 March 2023/in Featured Articles /by panglobal

Cushing’s syndrome is related to high production of cortisol and, without timely treatment, it can lead to complications such as heart attacks, strokes and type 2 diabetes. The condition can be diagnosed using a dexamethasone suppression test, which involves tracking the effects of this glucocorticoid medication on cortisol levels. Since the absorption of dexamethasone depends […]

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https://clinlabint.com/wp-content/uploads/sites/2/2023/03/px_1285217719-scaled-e1680865534896.jpg 600 900 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2023-03-23 12:24:272023-03-23 12:24:27Minimizing the number of false positives in dexamethasone suppression testing for the diagnosis of Cushing’s syndrome
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Next-generation apo(a) standardization: why, when and how?

, 23 March 2023/in Featured Articles /by panglobal

There is a revival of the genetically determined cardiovascular risk factor Lp(a). Yet, it is one of the most complicated clinical chemistry parameters, and up to 2-fold variation in measurement results may be observed between in vitro diagnostic tests. A next-generation reference measurement system based on mass spectrometry – and endorsed by the International Federation […]

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https://clinlabint.com/wp-content/uploads/sites/2/2023/03/Scherm­afbeelding-2023-03-23-om-12.55.42-2.png 1040 1848 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2023-03-23 12:08:522023-03-23 12:09:33Next-generation apo(a) standardization: why, when and how?
Figure1 edited

Role of AI in optimizing the whole-slide image acquisition workflow

, 24 January 2023/in Featured Articles /by panglobal

By Dr Maria Ada Prusicki Advances in whole-slide scanning technology enabled the automation of microscopy. Researchers can run image acquisition overnight and check the results remotely, minimizing the need for supervision and optimizing their use of time. Nonetheless, a few steps still require intense human supervision, especially for sample identification and scan area definition, where […]

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https://clinlabint.com/wp-content/uploads/sites/2/2023/01/Figure1_edited.png 457 1255 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2023-01-24 13:01:232023-01-24 13:01:23Role of AI in optimizing the whole-slide image acquisition workflow
Fig2 Anti Endomysium IIFT RGB

Antibody tests in the management and follow-up of coeliac disease

, 24 January 2023/in Featured Articles /by panglobal

by Dr Jacqueline Gosink In 2022, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) published a position paper on the management and follow-up of children and adolescents with coeliac disease (CD), following publication of new guidelines for the diagnosis of CD in 2020. This article discusses the different markers that can be used […]

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https://clinlabint.com/wp-content/uploads/sites/2/2023/01/Fig2-Anti-Endomysium-IIFT_RGB.jpg 258 2126 panglobal https://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png panglobal2023-01-24 11:37:002023-01-24 12:50:17Antibody tests in the management and follow-up of coeliac disease
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