by Dr Éva Mészáros Responding to a global health crisis: the evolution of the lab The COVID-19 pandemic forced life sciences laboratories all over the world to suddenly begin high volume PCR testing, to help gain the upper hand over this deadly disease. Many facilities had to adopt new pipetting platforms at short notice to […]
by Professor Stephen Bustin Remodelling qPCR as a tool for molecular diagnostics PCR is an incredibly powerful tool in the field of molecular diagnostics, and its current role is embedded in the clinical laboratory where it is indispensable for non-time-critical routine testing. However, point-of-care testing via lateral flow devices, as seen in the recent […]
‘The Expert Report to the Infected Blood Inquiry: Statistics’ (http://bitly.ws/EAng) found that around 3650 people with bleeding disorders in the UK were infected with HIV or hepatitis viruses through the use of contaminated blood products. In addition, many people (8120) were found to be chronically infected with hepatitis C 10 years or more after receiving […]
Clinical specimens, clinical trial samples and the information associated with them are precious resources that require careful curation. CLI caught up with David Kaye [Vice President and General Manager of BioFortis (a Q2 Solutions company)] to find out more about what this entails.
The investigation of antibodies against pathogenic agents in cerebrospinal fluid (CSF) samples is part of the diagnostic work up in acute or chronic inflammatory processes of the central nervous system. This article describes the analysis of intrathecally produced antibodies in CSF and the interpretation of the results.
What we learned from the last pandemic, which no one saw coming, is that it is difficult to answer the question “How should microbiology laboratories be prepared for the next unknown?” However, the last pandemic also taught us that it is imperative to try to answer such a question. In this article we will try […]
Cushing’s syndrome is related to high production of cortisol and, without timely treatment, it can lead to complications such as heart attacks, strokes and type 2 diabetes. The condition can be diagnosed using a dexamethasone suppression test, which involves tracking the effects of this glucocorticoid medication on cortisol levels. Since the absorption of dexamethasone depends […]
There is a revival of the genetically determined cardiovascular risk factor Lp(a). Yet, it is one of the most complicated clinical chemistry parameters, and up to 2-fold variation in measurement results may be observed between in vitro diagnostic tests. A next-generation reference measurement system based on mass spectrometry – and endorsed by the International Federation […]
By Dr Maria Ada Prusicki Advances in whole-slide scanning technology enabled the automation of microscopy. Researchers can run image acquisition overnight and check the results remotely, minimizing the need for supervision and optimizing their use of time. Nonetheless, a few steps still require intense human supervision, especially for sample identification and scan area definition, where […]
by Dr Jacqueline Gosink In 2022, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) published a position paper on the management and follow-up of children and adolescents with coeliac disease (CD), following publication of new guidelines for the diagnosis of CD in 2020. This article discusses the different markers that can be used […]