by Dr Cherie Ng and Dr Chaim Putterman Lupus nephritis is an immune-mediated glomerulonephritis that causes significant morbidity and mortality in patients with systemic lupus erythematous, a multisystem autoimmune disease. Non-invasive biomarkers are necessary to track disease and treatment response. Urinary ALCAM is a potential biomarker that samples the kidney and is relevant to the […]
Secretoneurin is a novel prognostic biomarker that may predict mortality in heart failure and the occurrence of ventricular arrhythmias. CLI caught up with Professor Torbjørn Omland (University of Oslo, Oslo, Norway) to find out more about it.
Those of you who regularly cast an eye over the Editor’s Letter in CLI will know that we have been closely following the story of the development of a sebum-based biomarker test to diagnose Parkinson’s disease (PD; Editor’s letters in the Feb/March issues of CLI in 2018 and 2021).
In spite of all the efforts over many years and decades to reduce malaria infection and deaths, the latest data from the World Health Organization (WHO) still show that in 2020 there were 241 million cases and 627 000 deaths. Of which, 95% of cases and 96% of deaths were in sub-Saharan Africa; 80% of […]
Li AT, Moussa A, Gus E et al. Ann Surg 2022;275(4):654–662
We are probably all familiar with the problems of information storage and retrieval, where transition to newer systems, platforms, databases, etc, can mean that information previously stored can no longer be accessed easily, if at all. This article discusses how a system of digital methodology has been developed that gives immediate visibility and clinical utility […]
Approaches, significance and challenges Cell proliferation is a hallmark of cancer associated with aggressiveness and response to chemotherapy. In breast cancer (BC), assessment of proliferation constitutes the main component of grading and help in management. Herein, we address the most common approaches for BC proliferation assessment, their limitations, and evolving applications to overcome these challenges.
The in situ stage of conjunctival squamous cell carcinoma is called conjunctival squamous intraepithelial neoplasia (CSIN). The use of terms such as Bowen’s disease and ocular surface squamous neoplasia are discouraged as their meanings vary and are prone to misinterpretation. The severity of squamous epithelial dysplasia is graded by the proportion of involved surface epithelium. […]
The recent COVID-19 pandemic and race to develop vaccines against the causative agent, severe acute respiratory syndrome coronavirus 2, has reminded us of the important role that protein glycosylation plays in the mechanisms of pathogen infection and host immune response. CLI caught up with Dr Sanda and Dr Campos (both at Team Scientific Service Group […]
The impact of the microbiome on a person’s health and disease is only slowly being fully realized. Here Bio-Me introduce themselves and their work to factor in the microbiome to the delivery of precision medicine.
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