Thiopurine pharmacogenomics and pregnancy in inflammatory bowel disease Andoh A, Kawahara M, Imai T, et al. J Gastroenterol 2021; 56(10): 881–890 The thiopurine drugs azathioprine and 6-mercaptopurine are widely used for the maintenance of clinical remission in steroid-dependent inflammatory bowel disease (IBD). Thiopurines are recommended to be continued throughout pregnancy in IBD patients, but conclusive […]
The COVID-19 outbreak caused by severe acute respiratory syndrome virus 2 (SARS-CoV-2) that was declared a pandemic in March 2020 has resulted in a the development of diagnostic tests and vaccines at an unprecedented speed. The development of de novo therapeutics, though, takes considerably longer, which is where the repurposing of existing drugs is being […]
The COVID-19 pandemic has reinforced the critical importance of diagnosis and access to these services, both at the individual and at a population level. The pandemic has also impacted the delivery of diagnostics and care for other medical conditions, such as HIV/AIDS, but similarly, lessons learned with COVID-19 can also be applied to improve diagnostic […]
Despite rapid advances in the areas of genomics and digital image analysis, cancer diagnosis remains largely reliant on tissue/cellular morphological assessment by an expert pathologist. Here, we summarize a newly developed approach to histology, based on a plasmon-induced colour change which provides instant, label-free visualization (or contrast) of cancer cells, distinguishing them from other cells […]
Therapeutic drug monitoring (TDM) of tacrolimus is mandatory because this immunosuppressive drug that is frequently prescribed in transplant patients, exhibits a high interpatient pharmacokinetic variability. This study explored the possibility of performing TDM using dried blood spots that can be collected by the patients themselves and that can be analysed by a fully-automated extraction module […]
The development of appropriate technical instrumentation for both sample and data analysis in recent years has driven progress in the field of metabolomics. CLI chatted to Dr Ali Tinazli (CEO at lifespin GmbH) to find out more about how this process of ‘digitizing health’ is developing and what it will mean for us as inidviduals.
In recent years, there has been a growing understanding of the pathology of autoimmune neurological disorders, and the identification of the causal autoantibodies has allowed the definition of new diseases. As these diseases have a multifaceted clinical presentation, comprehensive neural autoantibody testing is a central part of diagnosis. This article describe the current knowledge of […]
Recent advances are furthering our understanding of the role of iron in disease. CLI caught up with Professor Martina U. Muckenthaler and Dr Oriana Marques to learn more about the importance of iron homeostasis.
High-resolution mass spectrometry (MS) is a powerful analytical tool for clinical and forensic toxicology. It is capable of screening and confirming the presence of drugs and toxic compounds in various biological matrices. Using high-resolution MS/MS libraries helps to increase reporting confidence, verifies compound identification and reduces reporting of false-positive results.
The acute porphyrias are a group of rare genetic metabolic disorders of the heme biosynthesis pathway, that result in the toxic accumulation of porphyrin precursors, notably porphobilinogen and delta-aminolevulinic acid. This article provides an overview of the biochemistry and the diagnosis of acute hepatic porphyria, which is crucial to managing this condition appropriately, preventing and […]
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