Detection of cardiolipins using liquid chromatography-tandem mass spectrometry for diagnosis of Barth syndrome
By Dr Seul Kee Byeon and Dr Akhilesh Pandey An elevated ratio of monolysocardiolipin to cardiolipin is a hallmark feature of Barth syndrome, a genetic disorder caused by mutations in the TAFAZZIN gene. Liquid chromatography-tandem mass spectrometry can be used as a clinical laboratory test to calculate the ratios of monolysocardiolipins to cardiolipin species for […]