By Dr Stephen Langabeer The myeloproliferative neoplasms of polycythemia vera, essential thrombocythemia and primary myelofibrosis are clonal hematopoietic disorders characterized by an over-production of mature blood cells. Molecular evaluation is a key component of differentiating malignancy from a host of reactive causes with mutations in JAK2, CALR and MPL genes present in the majority of […]
Anyone who works in medical technology knows that the industry is currently focused obsessively on two prime targets – maximising the availability of self-testing and playing its part in the common goal to achieve net zero.
By Dr Daisuke Kawakami What is the new EU In Vitro
Aggregating clinical use and purposeful laboratory monitoring By Nicholas Armfield Ketamine is gaining attention as an analgesic, antidepressant and as a treatment for refractory status epilepticus. Ongoing support from the clinical laboratory is improving patient monitoring and increasing our understanding of ketamine as a clinical therapeutic. Low-dose intravenous and a relative high volume of distribution […]
by Dr Roopa Rao and Arden Shen The incidence of heart failure (HF) is increasing globally. Biomarkers in HF play a key role in diagnosis and prognostication. Ideal biomarkers should be easily measurable with distinct values in normal physiology, disease state and be a marker of therapeutic intervention. Several biomarkers have emerged that are potentially […]
By Dr Kyle H. Cichos and Dr Wilhelm Paulander This review examines periprosthetic joint infection (PJI) detection, highlighting the limitations of traditional methods and introducing isothermal microcalorimetry (IMC) as an innovative tool. IMC offers rapid, sensitive PJI detection, overcoming the challenges of culture-based and molecular diagnostics. Its potential applications in real-time monitoring, treatment efficacy, and […]
By Dr Seul Kee Byeon and Dr Akhilesh Pandey An elevated ratio of monolysocardiolipin to cardiolipin is a hallmark feature of Barth syndrome, a genetic disorder caused by mutations in the TAFAZZIN gene. Liquid chromatography-tandem mass spectrometry can be used as a clinical laboratory test to calculate the ratios of monolysocardiolipins to cardiolipin species for […]
Endometriosis is an incurable, chronic condition, associated with debilitating pain and reduced fertility. It is thought to affect 190 million women worldwide and is associated with huge costs to the economy though loss of earnings and cost of health-care/treatment. Currently, diagnosis on average takes around 8 years. CLI chatted to Dr Barbara Guinn (Centre for […]
Getting the most from every drop – new advances in blood separation Alexandra Sommer, Senior Product Manager, Clinical Diagnostics at Tecan
By Kellie Madigan The quality and consistency of immunostaining contributes highly to productivity for pathologists and cellular pathology laboratory managers. An evaluation study among key opinion-leaders in this area of healthcare has sought to understand how today’s pathologists perceive staining quality, its impact on their working life, and what the term ‘quality’ covers. This article […]
March 2026
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