Bio-Rad Laboratories has introduced four inhibitory antibodies that are highly specific to pertuzumab (Perjeta). These ready-made antibodies inhibit the binding of the drug to its target, human epidermal growth factor 2 (HER2), enabling researchers to develop highly selective and sensitive assays for bioanalysis and drug monitoring of pertuzumab and its biosimilars.

Pertuzumab is a targeted cancer drug that binds to the HER2 protein, which is overexpressed in HER2-positive cancers, preventing cell growth and proliferation. The new range of anti-pertuzumab antibodies includes monovalent Fab format antibodies suitable for the development of a pharmacokinetic bridging ELISA to measure free drug, as well as fully human IgG1 antibodies with varying levels of affinity, which can be used as a surrogate positive control or reference standard in an anti-drug antibody assay.

Recombinant, monoclonal anti-idiotypic antibodies

“We’re continuously introducing new ranges of recombinant, monoclonal anti-idiotypic antibodies to support researchers in developing robust methods that deliver reproducible and translatable results,” said Amanda Turner, Bio-Rad Product Manager, Life Science Group. “These sequence-defined reagents are well-characterized and non-animal-derived to ensure batch-to batch consistency and help reduce the use of animals in scientific research,” she said.

The antibodies are generated using the Human Combinatorial Antibody Libraries (HuCAL) and CysDisplay, a proprietary method of phage display, along with guided selection methods to obtain highly targeted reagents. The recombinant production method ensures a consistent and secure supply.

The anti-pertuzumab antibodies are approved for in vitro research purposes and for commercial services providing in vitro testing to support preclinical and clinical drug development.

• For more information, visit:  Bio-Rad – anti-pertuzumab-antibody-perjeta

Since the start of the COVID-19 pandemic, nations worldwide have vastly expanded their testing capacity by establishing huge networks of diagnostic testing facilities, including the public and private sector, and not-for-profit organizations.

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