Two innovative new ELISA systems provide separate detection of the diagnostically relevant antibodies in Bordetella pertussis infections: antibodies against pertussis toxin (PT) and antibodies against filamentous haemagglutinin (FHA). Independent determination of these antibodies is critical to enable a meaningful diagnostic interpretation, as emphasised in recent publications. Determination of IgG antibodies against PT is a front-line test for the serological diagnosis of pertussis infections; it is in many cases sufficient to perform a single determination of anti-PT IgG antibodies to detect an acute infection. Results of over 100 IU/mL provide a clear indication of a fresh infection or recent vaccination, and the second blood withdrawal can be omitted. If the titre is under 40 IU/mL no further tests are required unless clinical symptoms are suggestive of a pertussis infection. Only unclear results in the range 40 to 100 IU/mL need to be followed up with a second sample taken 7-10 days later. For a more in depth investigation, IgA antibodies against PT and IgG or IgA antibodies against FHA are measured separately. Age-dependent reference ranges are available on the internet.
The Anti-Bordetella pertussis Toxin ELISA (IgA or IgG) and the Anti-Bordetella FHA ELISA (IgA or IgG) correspond to current guidelines from European reference centres. Results are evaluated in international units (IU/mL) – a worldwide first for the detection of FHA antibodies. All processes, including incubation, evaluation and result archiving, can be fully automated. A supplementary product for Bordetella serodiagnostics, the immunoblot EUROLINE Bordetella pertussis (IgA or IgG), provides separate, parallel investigation of antibodies against adenylate cyclase toxin (ACT), PT and FHA and can also be fully automated using specially developed devices and software.
Read more

The Capillarys 3 system benefits from the latest technology advancements along with high throughput, high samples and reagents capacity, genuine walk-away, high-tech traceability, cap piercing and smart flexible workflow options. A variety of samples types can be used, serum, urine, whole blood, capillary blood and dry spots. Capillarys 3 works either dedicated to a high volume single assay or in multiassay mode. Using the well established Sebia capillary electrophoresis technology Capillarys 3 offers consistent results with current Capillarys/Minicap.
Read more

Available in 1mL, 2mL, 5mL, 10mL and 25mL volumes, Globe Scientific’s new plastic serological pipettes are manufactured as a single piece. Unlike other brands in which separate tip and mouth pieces are welded to the main body, the company’s one-piece seamless design eliminates the weld points that trap liquid. This unique design provides faster fill and release rates, ensures a complete flow out of the sample and offers a higher degree of accuracy. Each pipette has an aerosol barrier plug to prevent both liquid and aerosols from contaminating the pipettor. These serological pipettes are produced from crystal clear polystyrene and are colour coded for easy volume identification. The calibration of the pipettes is certified for accuracy. Sterile pipettes are RNase-free, DNase-free, non-pyrogenic, non-haemolytic and non-cytotoxic.
Read more

Apolipoprotein H (ApoH) is a major antigen for antiphospholipid antibodies present in patients with antiphospholipid syndrome (APS), which is related to venous and arterial thrombosis, fetal loss, and thrombocytopenia. Reports show that ApoH may function in blood coagulation and in the clearance of apoptotic bodies from circulation. Serum concentrations of ApoH have been found to be abnormal in patients with primary hyperlipidemia. Serum ApoH concentrations are increased in type 2 diabetes patients with microalbuminuria, suggesting a relationship with microvascular complications. ApoH was described as a major urinary protein in the urine of patients with renal tubular disorders such as Wilson´s disease, Dent´s syndrome, Fanconi´s syndrome and renal tubular acidosis. The Human ApoH ELISA kit extends BioVendor’s portfolio of diagnostic kits for lipoprotein metabolism, renal and cardiovascular disease and diabetology. Suitable for serum, plasma (EDTA, citrate, heparin) and urine samples, the 96 well-microtitre plate format is suitable for use with standard ELISA equipment.
Read more

Six new assays have been added to the menu on Binding Site’s SPAplus Specialist Protein Analyser. These include IgG in cerebrospinal fluid (CSF), IgA CSF, IgM CSF, Albumin CSF as well as Transferrin in serum, and C1 inactivator (C1 inhibitor) in serum and plasma. All six assays are fully automated, easy to use and provide quantitative results to aid the assessment of a patient’s immune system (CSF assays), iron deficiency anaemia (transferrin) and the investigation of hereditary angioedema (C1 inactivator).The SPAplus is ideal for carrying out these specialist protein assays and has been designed to bring together instrument, reagents and exceptional support as a package from a specialist protein focused supplier.The analyser is a compact, turbidimetric platform for specialist protein testing. Its fully automated system enables laboratories to maintain the quality of results and high throughput required for specialised protein assays. It can be placed alongside the laboratory’s main-line analysers or in other areas of the laboratory. Pre-programmed protocols developed and manufactured by the company provide highly sensitive and reproducible results that match or have greater sensitivity than nephelometry. The modular design with intuitive Windows based software makes the analyser very easy to use. It is engineered to a high standard demonstrating excellent reliability with minimal daily, weekly and monthly maintenance procedures.
Read more