Delivering increased sensitivity, the Triple Quad 6500 and QTRAP 6500 systems are next-generation mass spectrometers designed for those who need to push the limits of quantitation in complex matrices while maintaining reproducibility and robustness. With new multi-component Ion- Drive technology increasing the generation, transmission and detection of more ions, the instrument delivers sensitivity enhancements with no compromise in mass range. This is made possible by significant improvements in the ionization source through the new Turbo V source, enhancements in the ion transmission stage with the novel QJet guide, and a 20x increase to the detector dynamic range with the High Energy detector. The 6500 platform is also compatible with the novel SelexION Technology, which delivers a new dimension of selectivity in differential ion mobility spectrometry for quantitative and qualitative analysis. The 6500 series is ideally suited to a variety of applications, including drug discovery and development in regulated laboratories; peptide quantitation as well as biomarker verification in biomedical research; and clinical research in endocrinology laboratories.
Read more

Infection with Helicobacter pylori is estimated to affect 40 – 50 % of the population, and can have a significant impact on the treatment of patients with gastroduodenal diseases, gastric cancers and unexplained iron deficiency anaemia. The PYLORITOP Ag+ rapid visual assay for the detection of H. pylori in faecal samples is an immunochromatogenic test designed to provide clinical laboratories with a cost-effective assay to help meet current guidelines for the detection and treatment of H. pylori. The assay provides a quick noninvasive test for H. pylori infection, offering rapid qualitative results in just five minutes to help guide clinical pathways and avoid unnecessary treatments. Based on robust lateral flow technology, individually wrapped test cassettes are supplied with a sample collection tube for maximum convenience, and can be safely stored at room temperature for up to 12 months, providing a practical solution for H. pylori testing.
Read more

Combining fluorescence and brightfield analysis capabilities in a single platform, with precision cell modelling, Tissue IA 2.0 offers a superior solution for IHC biomarker quantification. A major challenge in research today is retrieval of quantitative, reproducible data from tissue-based IHC studies. This platform provides expert tools for researchers to extract the most from their studies. Powerful colour separation and multi-marker colocalisation functionality provides advanced insight and unbiased measurement of multiple antigen immunostaining in brightfield or fluorescent samples. Sophisticated cell modelling accurately detects and quantifies differential expression of staining in cellular compartments, providing detailed insight into cytoplasmic, membrane and nuclear biomarker localisation. The advanced dual staining capabilities enable cell cohorts at the molecular level to be identified. One marker can identify a population of interest and expression of a second can be quantified, providing exceptional analysis performance and greater understanding of slides. With high throughput batch analysis capacity, the platform will process whole slides, regions of interest or tissue microarray cores, and automatically integrate analysis results with a user’s slides.
Read more

Apolipoprotein H (ApoH) is a major antigen for antiphospholipid antibodies present in patients with antiphospholipid syndrome (APS), which is related to venous and arterial thrombosis, fetal loss, and thrombocytopenia. Reports show that ApoH may function in blood coagulation and in the clearance of apoptotic bodies from circulation. Serum concentrations of ApoH have been found to be abnormal in patients with primary hyperlipidemia. Serum ApoH concentrations are increased in type 2 diabetes patients with microalbuminuria, suggesting a relationship with microvascular complications. ApoH was described as a major urinary protein in the urine of patients with renal tubular disorders such as Wilson´s disease, Dent´s syndrome, Fanconi´s syndrome and renal tubular acidosis. The Human ApoH ELISA kit extends BioVendor’s portfolio of diagnostic kits for lipoprotein metabolism, renal and cardiovascular disease and diabetology. Suitable for serum, plasma (EDTA, citrate, heparin) and urine samples, the 96 well-microtitre plate format is suitable for use with standard ELISA equipment.
Read more

Six new assays have been added to the menu on Binding Site’s SPAplus Specialist Protein Analyser. These include IgG in cerebrospinal fluid (CSF), IgA CSF, IgM CSF, Albumin CSF as well as Transferrin in serum, and C1 inactivator (C1 inhibitor) in serum and plasma. All six assays are fully automated, easy to use and provide quantitative results to aid the assessment of a patient’s immune system (CSF assays), iron deficiency anaemia (transferrin) and the investigation of hereditary angioedema (C1 inactivator).The SPAplus is ideal for carrying out these specialist protein assays and has been designed to bring together instrument, reagents and exceptional support as a package from a specialist protein focused supplier.The analyser is a compact, turbidimetric platform for specialist protein testing. Its fully automated system enables laboratories to maintain the quality of results and high throughput required for specialised protein assays. It can be placed alongside the laboratory’s main-line analysers or in other areas of the laboratory. Pre-programmed protocols developed and manufactured by the company provide highly sensitive and reproducible results that match or have greater sensitivity than nephelometry. The modular design with intuitive Windows based software makes the analyser very easy to use. It is engineered to a high standard demonstrating excellent reliability with minimal daily, weekly and monthly maintenance procedures.
Read more