The novel CytoBead technology offers for the first time the combination of autoantibody analysis by cell-based screening and the confirmation of the corresponding autoantigen reactivities by multiplexing, using the immunofluorescence technique (IFT) in one reaction environment. The CytoBead ANCA for example allows the screening of antineutrophil cytoplamsic antibodies (ANCA) on ethanol-fixed neutrophiles and the confirmation thereof using proteinase 3 (PR3) and myeloperoxidase (MPO) coated microbeads. Furthermore, the detection of Goodpasture antibodies, which can occur in 10% of rapid progressive glomerulonephritis patients, is integrated by adding glomerular basement membrane (GBM) coated microbeads. Additionally, this technology provides an ideal reaction environment for multiplexing antinuclear antibody (ANA) assessment and the detection of celiac disease specific antibodies. This assay format can be interpreted with a standard fluorescence microscope for semi-quantitative analysis and with the automated interpretation system Aklides for quantitative testing. CytoBead technology is an attractive alternative to classical, time-consuming single parameter antibody detection and is applicable for high throughput routine diagnostics.
Read more

A new strip-based test for quick and easy hemoglobin analysis for anemia determination is now available. STAT-Site M Hgb is a pocket-sized device that reliably delivers accurate hemoglobin analysis results within 30 seconds from 15 μL of finger-prick whole blood. This hemoglobin photometer is maintenance-free, and features intuitive, step by step on-screen instructions minimize training and ensure ease of use. Due to its durability, portability and userfriendliness, STAT-Site M Hgb is especially suited to blood screening programmes in developing world markets, but it also has a niche in settings where operators are mobile. Using just one 3V Li type battery for every 1,000 tests and with an operating temperature range of 16° to 35°C, the analyser is ideal for field use.
Read more

Offering significant improvements in workflow optimization, particularly when multiple protocols are used, the Gemini AS advanced automated stainer has been intelligently designed to be easier to use than ever, with a new touch screen interface and intuitive software. The instrument has an all-new touchscreen interface that is intuitive to use and makes day-to-day operation simplicity itself. A glance is all that is needed to check the batch stain progress. New LED lighting allows the operator a clear view of what is going on inside the staining area. It is also fully compatible with the Thermo Scientific range of coverslippers to match the workflow of modern high-throughput laboratories. To maximize throughput, up to 12 slide racks can be processed at the same time. The control software automatically arranges the reagent positions for greatest speed and performance. Furthermore, duplicate reagents can be assigned automatically according to QC usage values to reduce downtime to change reagents. Gemini AS has 26 different reagent stations, catering for both H&H and Papanicolaou stains without changing reagent pots. Once the racks are loaded and the protocols are selected, the intelligent software does the rest. Furthermore, the instrument has been configured for more application-specific staining requirements such as those for cytogenetics and andrology. The instrument’s dual-layer configuration makes the most use of laboratory space. Also featured is a built-in power supply for protection of valuable samples. Protocols are easy to prepare and readily modified, and the manufacturer’s recommended protocols are pre-installed. A USB port allows data to be downloaded for off-line processing and analysis.

Read more

A new α1-microglobulin test has been developed for the determination of this excellent marker for the evaluation of renal tubular function. α1-microglobulin is also elevated in heavy metal poisoning, following renal colic, decreased glomerular filtration and renal disease associated with diabetes. After its secretion into the blood, α1-microglobulin is found in free form and in a wide variety of complexes. Only the free form of α1-microglobulin is filtered through the glomerulus and then reabsorbed by the proximal tubule of the nephron where it is degraded. In conditions with impaired tubular function, α1-microglobulin reabsorption decreases and its concentration in urine increases. This turbidimetry reagent is available in Manual and Automated Systems Reagents presentations.
Read more

A complete range of kits for the testing of urinary proteins is available. Such tests are particularly useful from a diagnostic viewpoint, providing important information for the diagnosis of renal diseases, monitoring and differential analysis of proteinurias. All reagents are latex-based, ready-to-use and validated according to the international CLSI protocols. Within the range, urinary-Transferrin, urinary-Albumin (micro-albuminuria), and urinary-IgG, are of paramount importance. Albuminuria is one of the most important markers for damages to the endothelium. Pathological levels of urinary albumin (micro-albuminuria) are present in diabetes, hypertension, and during the early stages of preeclampsia. Transferrin and albumin together are pathognomonic of selective glomerular proteinuria. If the IgG levels rise the glomerular proteinuria becomes non selective. The accuracy guaranteed by the method allows correct calculation of the Cameron index (ratio between IgG clearance and transferrin clearance). The urinary proteins kits are available as both turbidimetry and nephelometry. The dedicated product lines include calibrators and controls whose assigned values are in accordance with International Scientific Committee’s guidelines. All urine testing products from Sclavo are available in specific formats and packaging developed for all Sclavo Systems (Sclavo Palio, Dirui, Konelab), Sclavo EasyNeph (nephelometry), in addition to the multi-purpose format. Along with specific proteins kits, the company offers a dedicated kit for testing total urinary proteins, highly sensitive to both tubular proteins, as well as Bence-Jones proteinuria, ensuring reliable and accurate results.

Read more