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Author Archive for: 3wmedia
Entries by 3wmedia
Towards meeting the global requirement for safe blood
According to the WHO, an estimated 2 % of the world’s population needs to regularly donate blood to ensure that supply meets demand. Currently approximately 85 million units of red blood cells, the most frequently transfused blood product, are provided per annum globally. Over half the recipients, predominantly in the less developed countries, are children […]
Liquid biopsy for diagnostic epidermal growth factor receptor gene testing in non-small cell lung cancer
Advances in circulating biomarker research have led to the use of blood samples to characterize cancer patients’ tumour DNA where a lack of tumour tissue prevents molecular testing. This is critical for non-small cell lung cancer (NSCLC) patients who require tumour molecular characterization in order to access life-extending treatments that would be denied without biopsy. […]
Diagnosis of the intestinal parasite Strongyloides stercoralis by detection of cell-free parasite DNA fragments in urine
Diagnosis of infection with the parasitic roundworm Strongyloides stercoralis is currently done by stool sample culture to detect active larvae. However, the sensitivity of this method can be as low as 28%. This article describes how cell-free parasite DNA can be detected in urine when the results of stool-sample testing are negative. by Dr Clive […]
Cascade screening of relatives for familiar hypercholesterolemia: detection of low density lipoprotein receptor gene mutations using real-time PCR
Early detection of disease-associated mutations in patients with familial hypercholesterolemia (FH) is crucial for early interventions that can reduce the risk of cardiovascular disease. Here, we describe real-time PCR-based approaches for the rapid detection of single nucleotide substitutions or insertions of the low density lipoprotein receptor gene for cascade screening of relatives. by Sarojini Pandey […]
Circulating biomarker use for the prediction and detection of pre-eclampsia
Pre-eclampsia is a major cause of maternal and perinatal mortality. Scientific advances in recent decades have meant new possibilities for enhancing the prediction and diagnosis of pre-eclampsia. Here we detail current biomarker-based approaches under development or validated for clinical translation that will revolutionize obstetric practice in the years ahead. by Dr Kirsten Palmer1, Associate Professor […]