Leiomyosarcoma and endometrial stromal sarcoma are the most common types of uterine sarcoma, a group of rare and clinically aggressive mesenchymal cancers. These two sarcomas may have overlapping clinical presentation, morphology and protein expression profiles, making their diagnosis occasionally difficult. This article discusses molecular approaches that may be applied to the diagnosis of these two […]
Alterations of the microbiome are associated with colorectal cancer. Research suggests that microbiome data could improve colorectal cancer screening. Analysis of the microbiome directly from existing screening methods offers the opportunity to rapidly translate this research into practice, with the potential to develop a multifactorial colorectal cancer screening tool. by Dr Caroline Young and Professor […]
Neuroendocrine tumours (NETs) are a heterogeneous group of tumours that vary depending on their anatomical sites, functionality and hormones produced. They are often silent clinically, and diagnosis is usually delayed. Chromogranin A (CgA) is the best-known general biomarker which is used for the diagnosis and management of NETs. It can be measured in serum or […]
Hyperthyroidism can result from a number of different disorders including Graves’ disease. The diagnostic gold standard is based on radiological tests but measurement of thyroid stimulating hormone receptor antibodies plays an important role in the diagnosis of Graves’. It is important to understand the diagnostic strengths and limitations of these measurements. by Dr Christopher Boot […]
Mild hypothyroidism, where plasma levels of thyroid stimulating hormone (TSH) are above the ‘normal’ upper limit but where there is no equivalent change in circulating levels of the thyroid hormones tetraiodothyronine (T4) and triiodothyronine (T3), is common in women of childbearing age; the condition is found in up to 3?% of pregnant women. While normally […]
Highly sensitive stool DNA testing of Fusobacterium nucleatum as a marker for detection of colorectal tumours in a Japanese population Suehiro Y, Sakai K, Nishioka M, Hashimoto S, Takami T, Higaki S, Shindo Y, Hazama S, Oka M, Nagano H, Sakaida I, Yamasaki T. Ann Clin Biochem. 2016; pii: 0004563216643970. [Epub ahead of print] BACKGROUND: […]
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