Acute kidney injury is a common and serious complication of many hospital admissions, yet there are often delays in recognizing its development. The laboratory can play a key role in ensuring large increases in serum creatinine do not go unnoticed so that deteriorating patients receive prompt medical attention. by Nick Flynn IntroductionAcute kidney injury (AKI) […]
Affecting around one in twenty pregnancies, pre-eclampsia is a leading cause of fetal morbidity and mortality globally. Around half a million babies die as a result of the condition annually. Severe pre-eclampsia, leading to eclampsia characterized by seizures, is also the second leading cause of maternal mortality (after hemorrhage) in most countries: an estimated 76,000 […]
Preimplantation genetic screening is a diagnostic approach dedicated to patients undergoing IVF with the proper indications (advanced maternal age, recurrent implantation failure, recurrent pregnancy loss) in order to increase pregnancy rates per transfer via euploid embryo selection. This strategy, and all the associated techniques, are in constant evolution and will shed more light on unexplored […]
Inconsistent detection and false-positive rates have plagued traditional screening measures for trisomy, thus encouraging the development of less risky and invasive measures. Through the advent of single-nucleotide polymorphism-based and informatics-based non-invasive prenatal testing, accurate detection of trisomies 13, 18, 21 as well as the X and Y chromosomal aneuploidies of XXY, XYY and XXX in […]
Prostate specific antigen (PSA) has significantly improved the early detection of prostate cancer (PCa), reducing the related mortality rate. However, PSA has a low specificity, being affected by many benign conditions. [-2]proPSA, a PSA precursor, is a more specific and accurate biomarker indicating prostate biopsy in men at real risk of PCa. by Dr A. […]
Autoimmune diseases affect approximately 5 % of the population of developed countries with an increasing incidence. Analysis of disease-associated autoantibodies (AAb) plays a significant role in the differential diagnosis thereof. Indirect immunofluorescence (IIF) has been established as the gold standard for AAb screening in particular for systemic rheumatic diseases. In the recommended two-tier approach for […]
by James D. Peele, PhD The HEp-2 immunofluorescence assay (IFA) for ANA screening is excellent for ruling out many connective tissue diseases, but a positive result seldom translates into a clinically meaningful diagnosis. A new automated, efficient, enzyme immunoassay for ANA screening provides reliable, objective information that can be applied clinically with confidence.
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