Vitamin D is derived from food, and human beings need exposure to sunlight for its synthesis. This is achieved through the absorption of ultraviolet B radiation by 7-dehydrocholesterol in the skin. However, certain sections of the population cannot produce Vitamin D in sufficient quantities; such at-risk groups are the focus of screening. The principal function […]
The measurement of 25-hydroxyvitamin D [25(OH)D] levels is affected by assay interference and variability. This article describes the steps that are being taken to improve assay standardization. by Prof. Etienne Cavalier and Dr Jean-Claude Souberielle BackgroundThe number of 25-hydroxyvitamin D [25(OH)D] determinations has dramatically increased over the last ten years. This increase can be explained […]
With research demonstrating the impact of vitamin D on a range of conditions, the importance of adequate levels of vitamin D is often in the spotlight. This has resulted in increased rates of testing from both GPs and self-referring individuals. by Robyn Shea and Dr Jonathan Berg BackgroundVitamin D is an essential nutrient required for […]
Gastric adenocarcinoma is usually diagnosed at an advanced stage, which portends a poor prognosis. Molecular biomarkers are important tools to understand the underlying biology of its aggressive behaviour and to discover new targets for therapeutic agents. Microarray analyses and next generation sequencing are leading to a deeper understanding of tumour biology and the development of […]
B-cell maturation antigen (BCMA) was originally identified as a cell surface receptor expressed on late-stage B cells, plasma cells, and B-cell malignancies including multiple myeloma (MM). We recently discovered that BCMA is shed into the blood of MM patients, and, therefore, serum BCMA may serve as a new prognostic marker to track disease status and […]
Many potential cancer biomarkers have been identified, however, the transfer of these biomarkers from discovery to clinical practice is still a process filled with pitfalls and limitations. To prove clinical utility and performance, these candidate biomarkers need to be reproducible, specific, sensitive, and validated using large sample cohorts, all of which require development of robust […]
Expressed prostatic secretion (EPS) is obtained after prostatic message by milking the urethra and collecting fluid directly from the urethral meatus. Clinicians have previously used this biospecimen primarily for the diagnosis of urinary infections. More recently it has been recognized as a rich source of biomarkers of prostate malignancy. Many of those biomarkers are accessible […]
by Minjie Wang, Binbin Han, Xuexiang Li, Jun Qi Tumour markers play an important role in the detection and management of cancer. It is critical to evaluate new assay systems for precise measurement of commonly used tumour markers in the clinical setting. The goal of this study is to evaluate the performance of […]
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