Autoantibodies against phospholipase A2 receptors (PLA2R) are a new, highly specific diagnostic marker for primary membranous nephropathy (MN). Detection of anti-PLA2R using easy-to-perform and inexpensive serological assays can indicate primary MN in patients suffering from nephrotic syndrome and secure a differential diagnosis from secondary MN. Anti-PLA2R analysis is also useful for determining the disease activity, […]
Aminoglycosides are antibiotics largely used at the hospital. Their nephrotoxicity imposes therapeutic drug monitoring as well as kidney function monitoring. Creatinine is the most widely used biochemical marker; however, new biomarkers such as neutrophil gelatinase associated lipocalin (NGAL), cystatin C (Cys C) or kidney injury molecule-1 (KIM-1) can allow the detection of acute kidney injury […]
An accurate measure of glomerular filtration rate (GFR) is required in a variety of clinical situations. Plasma creatinine and creatinine-based equations have served as convenient estimates of GFR but they are subject to limitations. Formal assessment of GFR using clearance methods traditionally necessitates the use of radioactive traces such as 51Cr-EDTA. More recently, iohexol has […]
A growing challenge for nephrologists is to quickly identify patients with chronic kidney disease (CKD). Experts believe there is now “coherent, undisputable evidence” that timely treatment of CKD can delay the onset of end-stage renal failure (ESRF). The challenge of timely diagnosisSeveral studies suggest that early identification and management of CKD can reduce the risk […]
Patient testing is increasingly being carried out at the bedside. Indeed the availability of point-of-care testing (POCT) instruments and devices has grown significantly in recent years. Undoubtedly POCT helps speed up the availability of results, but when such testing is moved outside of the laboratory setting how can accuracy be ensured? ` by Sarah Kee […]
Developed countries have not escaped the rise in cases of multidrug-resistant tuberculosis. In the UK a mobile X-ray unit has been operating in London since 2005 and this service has been augmented with point-of-care testing (POCT) since 2011. POCT has been well received by patients and has greatly reduced the number of unnecessary hospital visits. […]
June 2026
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