The detection of liver/kidney/microsomal antibodies (LKM) is one of the most common analytical procedures performed in the autoimmunity laboratory. Several techniques can be currently adopted that allow the detection of LKM in patient serum, such as ELISA, line immunoassay or indirect immunofluorescence. Far from being outdated, indirect immunofluorescence is the major method used for the […]
Apitope, the drug discovery and development company focused on disease-modifying treatments for patients with autoimmune and allergic diseases, announced today that Bristol University research led by Apitope Founder and CSO, Prof David Wraith, on its treatment approach to autoimmune diseases, such as Multiple Sclerosis (MS), has been published in Nature Communications. The researchers at the […]
The spectrum of autoimmune neurological syndromes has expanded substantially in the last fifteen years because of the discovery of novel anti-neuronal autoantibodies. Today’s autoantibody test portfolio includes over 32 different specificities associated with neurological diseases.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with diverse clinical manifestations. Accurate diagnosis, prediction of disease activity, organ involvement and management remains problematic owing to a lack of reliable biomarkers. This article reviews traditional and a few promising candidate biomarkers in SLE with specific clinical implications. by Dr Anne E. Tebo BackgroundSystemic […]
Rheumatoid arthritis is a systemic autoimmune disease that is an important socio-economic health problem. Recent evidence about the immunopathogenesis of this disorder might open new perspectives for a more appropriate laboratory approach. In this review, our attention is focused on the clinical relevance and appropriateness of laboratory biomarkers correlated with early diagnosis, prognosis, evolutive aspects […]
Pharmacogenomic research has been active in the area of hepatitis C virus infection. Both viral and host polymorphisms are discussed in this review to describe how the genotype information helps predict response to conventional peginterferon alfa and ribavirin therapy as well as more recently recommended direct-acting antivirals, simeprevir and sofosbuvir. by M. Kawaguchi-Suzuki and Dr […]
Pharmacogenomics analyses the response of individual patients to a medicinal product, to optimize therapy, obtain maximum efficacy and minimize its side effects. Pharmacogenomics is now increasingly accepted to encompass pharmacogenetics, which focuses only on heritable biomarkers. Unlike the latter, pharmacogenomics also includes the study of proteins and enzymes as biomarkers.The proponents of pharmacogenomics believe it […]
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