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Author Archive for: 3wmedia
Entries by 3wmedia
Ovarian reserve and beyond: AMH’s role in women’s reproductive health
The human gene for anti-Müllerian hormone (AMH) was isolated and sequenced 20 years ago [1], with the first immunoassays developed in 1990 [2,3]. Since then, our understanding of this hormone has significantly increased, with most clinical use today focusing on women’s reproductive health. AMH’s ability to reflect the number of small antral and pre-antral follicles […]
Clinical application of NGS – ensuring quality
Advances in Next Generation Sequencing (NGS) are bringing much higher throughput and rapidly reducing costs, whilst facilitating new mechanisms for disease prediction. Consequently, the clinical applications of NGS technologies are continuing to develop, with the potential to change the face of genetic medicine [1]. by Hannah Murfet (BSc, PCQI), Product Quality Manager, Horizon Discovery Applications […]
The clinical lab and pharmacogenomics – bridging the last mile
Pharmacogenomics analyses the response of individual patients to a medicinal product, to optimize therapy, obtain maximum efficacy and minimize its side effects. Pharmacogenomics is now increasingly accepted to encompass pharmacogenetics, which focuses only on heritable biomarkers. Unlike the latter, pharmacogenomics also includes the study of proteins and enzymes as biomarkers.The proponents of pharmacogenomics believe it […]
Pharmacogenomics and therapy for hepatitis C virus infection
Pharmacogenomic research has been active in the area of hepatitis C virus infection. Both viral and host polymorphisms are discussed in this review to describe how the genotype information helps predict response to conventional peginterferon alfa and ribavirin therapy as well as more recently recommended direct-acting antivirals, simeprevir and sofosbuvir. by M. Kawaguchi-Suzuki and Dr […]