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21

The role of protein S-acylation in cardiac function

by Dr O. Robertson-Gray and Dr W. Fuller Cardiovascular disease (CVD) is the umbrella term for conditions affecting the heart or blood vessels and remains the leading cause of death worldwide. New therapeutic strategies to aid in the prevention and treatment of CVD are therefore necessary. This article discusses the potential for S-acylation, a post-translational […]

23

Carbohydrate-deficient transferrin testing: a truly traceable and specific biomarker for chronic alcohol misuse

by Jean Deenmamode The concept of testing breath, blood or urine for alcohol is familiar to the general public, and blood alcohol testing is widely used across a range of industries, from aviation to driver licensing. But is a snapshot alcohol measurement really the best approach to ensuring longterm safety in these industries, or identifying […]

25

Digital pathology in the clinical lab

Histopathology is a crucial stage in the diagnosis of many diseases, particularly cancer staging and therapy management. Current challenges facing pathology are a shortage of pathologists and an increasing workload resulting from expanded screening programmes, increased test complexity and an increasing elderly population. Leeds Teaching Hospitals NHS Trust, UK, has a fully subspecialized diagnostic histopathology […]

26

Artificial intelligence is the key driver for digital pathology adoption

by Dr Mustafa Yousif, Dr David S. McClintock and Dr Keluo Yao Artificial intelligence (AI) has the potential to optimize anatomic pathology (AP) laboratory efficiency, enhance pathologists’ diagnostic skills, elevate case reimbursement and, ultimately, improve patient care. To realize this potential, AP laboratories must overcome the barriers to adopting digital pathology (DP) while DP vendors […]

27

Value of calprotectin analysis

by Dr Ruth Ayling Calprotectin is a protein derived from neutrophils and its presence in feces can be used as a surrogate marker of gastrointestinal inflammation. Measurement is useful to differentiate inflammatory bowel disorder (IBD) from functional bowel disease, which has similar clinical features but different etiology, and to manage patients with established IBD.

28

A brief review of heparin-induced thrombocytopenia and diagnostic considerations

by Dr Christina C. Pierre and Dr Lindsay Bazydlo Heparin-induced thrombocytopenia (HIT) is a hypercoagulable disorder that is mediated by antibodies against heparin complexed to platelet factor 4. HIT antibodies activate platelets, which generate a self-propagating, pro-coagulant state. A subset of patients with HIT develop thrombosis that can be limb- and/or life-threatening. This review provides […]

29

Monitoring therapeutic drug dosage in rheumatic diseases, chronic inflammatory bowel diseases and psoriasis

by Dr Jacqueline Gosink Tumour necrosis factor (TNF) inhibitors are increasingly used to treat chronic inflammatory bowel diseases, rheumatic diseases and psoriasis. Continuous drug level monitoring and administration interval adjustment accompanying the treatment with TNF inhibitors is the key to successful, individualized and targeted patient care. Concentrations of the TNF inhibitors adalimumab or infliximab can […]

30

Insight into high-sensitivity troponin tests for the early rule-out of NSTEMI

In August 2020 new guidance was issued by the National Institut e for Health and Care Excellence on the use of high-sensitivity troponin tests for the early rule-out of non-ST-elevation myocardial infarction (NSTEMI). CLI caught up with Heather Read-Harper from Beckman Coulter to find out more about the use of cardiac troponin biomarkers in the […]