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In vitro determination of specific IgE is nowadays a central pillar of allergy diagnostics. Specific IgE against up to 54 allergens can be investigated in parallel using the EUROLINE immunoblot system. Individual EUROLINE profiles are targeted to specific indications, encompassing food, inhalation, atopy, insect venoms and pediatrics, while diverse region-specific profiles take into account local […]
Acinetobacter baumannii is a prevalent nosocomial pathogen with a high incidence of multidrug resistance. Treatment of infections with colistin can result in emergence of colistin-resistant strains. This occurs via modifications of the phosphate moieties of lipopolysaccharide-derived lipid A, which are readily identified by mass spectrometry (MS). In this article, we describe colistin susceptibility determinations by […]
Quantitative specific drug analysis by tandem mass spectrometry allows a wide range of drugs to be analysed in either urine or oral fluid to confirmation standards. The repertoire of drugs is based on drugs of abuse implicated in drug-related deaths in Scotland and currently includes 27 specific drugs and metabolites. by Dr Paul Cawood and […]
The global eradication of malaria is a challenging, although perhaps not impossible, aim: Paraguay was recently declared malaria-free and, according to the World Health Organization, Algeria, Argentina and Uzbekistan are likely to be declared malaria free by the end of the year. Several tactics are being used to prevent infection, including preventing mosquito bites by […]
Recently I heard on BBC Radio 4 a fascinating interview of Professor George Jelineck by Caroline Quentin, both of whom suffer from multiple sclerosis (MS). MS, as no doubt you know, is a condition caused by the demyelination of neurons as the result of attack by the body’s own Th1 cells, usually resulting in progressive […]
Extraction of nucleic acids from patient samples is an essential step for downstream molecular studies such as quantitative and qualitative PCR. The size of the DNA fragments present in samples can influence extraction efficiency, especially observed in circulating cell-free DNA (cfDNA). Further work is necessary to determine the impact of cfDNA extraction on clinical virology […]
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