Since the 1960s, the use of dried blood spot (DBS) technology for newborn screening (NBS) and monitoring of patients with inherited metabolic disorders (IMDs) has become routine in most parts of the world.
Accurate interpretation of laboratory tests is essential to diagnosis and monitoring of many pediatric disorders. Hematology test results in children cannot be interpreted using adult reference intervals owing to the vast changes that occur throughout childhood from the neonatal period to adolescence. Consequently, the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) programme has recently […]
Cardiac surgery with cardiopulmonary bypass is associated with significant alterations in the hemostatic system. Standard laboratory coagulation tests are frequently used to assess coagulopathies and to guide hemostatic interventions. However, these tests present major limitations. Viscoelastic testing in conjunction with the implementation of a specific algorithm for coagulation management in cardiac surgery enables better control […]
Controls are a crucial part of any assay. Without them, our work is, at best, simply a waste of time and reagents. We know we need them but we probably should give them much more thought than we do. CLI caught up with Dr John Hedges, Director of Research and Development at Asuragen (a Bio-Techne […]
The diagnosis of fungal infections of the skin and nails has undergone a paradigm shift in recent years. Traditional culturing methods have in many cases been replaced by PCR-based diagnostics, which provide greater accuracy and yield results ina fraction of the time. The fast, differentiated detection of dermatomycosis pathogens enables prompt targeted treatment of infections.
Urothelial carcinoma is a common cancer and patients with metastatic urothelial cancer (mUC) have very poor outcomes. Many mUC patients do not have durable responses to systemic treatment and are exposed to toxic side effects that negatively impact the patient’s quality of life. Identifying novel biomarkers for therapy and selecting the best treatment option for […]
Quantification of M-proteins plays an important role in diagnosing and managing patients with monoclonal gammopathies. This is traditionally performed by integrating abnormal monoclonal peaks in the electrophoretogram, using either a perpendicular drop (PD) or tangential skim (TS) method. In this article, we describe the advantages and disadvantages of the PD and TS integration methods and […]
In April 2020, the Royal College of Pathologists published recommendations for a set of blood COVID-19 biomarkers to monitor disease severity and progression, which have since been employed by many UK hospital diagnostics services. Subsequent findings regarding biomarkers and their ability to distinguish or predict severe disease remain under investigation and emerging evidence highlights that […]
by Niels Kruize, CCO, MolGen “Automation and industrialization of COVID-19 PCR-testing will facilitate an immense scale-up of the global PCR-testing capacity. It will allow for a new approach to keep society open: preventive, regular testing (twice per week), which will create green bubbles and get us ahead of the curve” – Niels Kruize, CCO, MolGen
Despite the enormous success of mumps vaccination campaigns around the world, there has recently been a significant increase in mumps cases and outbreaks in vaccinated populations. As a result, tracking the molecular epidemiology of mumps outbreaks has increased in importance. Here we examine the challenges and limitations associated with traditional molecular genotyping tools and compare […]
November 2025
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