Assessment of minimal residual disease during B-cell precursor acute lymphoblastic leukemia provides a good indication of therapy response and prognosis. This investigation can be done in several ways, including flow cytometry. Techniques in this field have developed in recent years and CLI chatted to Dr van der Velden (Department of Immunology, Erasmus University Medical Center, […]
For both the patient journey and laboratory efficiency, when diagnosing infectious diseases it is important to get it right and to get it right the first time. CLI caught up with Dr Gaiane Demirdjian, Director of Research & Development at Beckman Coulter Diagnostics, to find out more about how their new line of infectious disease […]
by Dr Jacqueline Gosink Bone turnover markers (BTMs) provide a non-invasive method to assess bone remodelling – the process by which old bone tissue is removed and replaced. Measurement of BTMs supports diagnosis of metabolic bone diseases, such as Paget’s disease, and is a useful aid for monitoring therapy responses in osteoporosis. Panels of peptide […]
by Dr Dagmara Lewandowska Peri-implantitis and mucositis are common inflammatory microbial-biofilm diseases affecting tissues surrounding dental implants. Understanding the human oral microbiome may hold the key to developing tailored and highly effective personalized treatments for these diseases. Liquid-handling automation, combined with magnetic bead separation, enables reliable, high-throughput next-generation sequencing library preparation for this crucial microbiome […]
With an increasingly elderly population, joint replacement surgery is being performed more and more often. Infection around the prosthesis is becoming a more common reason for revision surgery and appropriate antibiotic treatment benefits from accurate diagnosis of the pathogen(s) involved. Current protocols use a standard 10- to 14-day incubation period but a recent publication has […]
What is protein glycosylation? There are several types of post-translational modifications (PTMs) that proteins can undergo. Phosphorylation, methylation and acetylation all involve the addition of small chemical groups which affect function. Ubiquitylation involves the addition of the small peptide, ubiquitin, which targets proteins for degradation. Glycosylation is one of the more complex forms of PTM, […]
by Dr Gard Myrmel We have known for a while now that the symptoms of acute coronary syndromes can be different for women compared to men. Here, Dr Myrmel discusses how the differences between the sexes also extend to the prognostic value of circulating biomarkers in patients presenting with acute chest pain.
by PD Dr Angelika Hammerer-Lercher Measurement of cardiac-specific troponin I or T forms is part of the diagnostic pathway to rule in or rule out acute coronary syndromes, such as heart attack, as well as for prognostication of future cardiovascular disease. CLI chatted to Dr Angelika Hammerer-Lercher (Chief Physician and Director of Central Medical Laboratories, […]
by Dr Aleksandra Havelka Assays for NT-proBNP form a key part of diagnosing/ruling out, predicting and managing heart failure. CLI chatted to Dr Aleksandra Havelka (Gentian Diagnostics) to find out more about the challenges and limitations of measuring NT-proBNP concentrations, particularly the effects of glycosylation, and what developments are on the horizon to overcome these […]
by Dr Osaretin Emmanuel Asowata The detection of Pneumocystis jirovecii in immunocompromised patients is crucial for the treatment of Pneumocystis jirovecii pneumonia (PCP) and to prevent invasive infection. However, PCP can be challenging to diagnose clinically, as symptoms are non-specific. There are several laboratory methods that can be used to diagnose PCP and their advantages […]
November 2025
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