With an increasingly elderly population, joint replacement surgery is being performed more and more often. Infection around the prosthesis is becoming a more common reason for revision surgery and appropriate antibiotic treatment benefits from accurate diagnosis of the pathogen(s) involved. Current protocols use a standard 10- to 14-day incubation period but a recent publication has […]
What is protein glycosylation? There are several types of post-translational modifications (PTMs) that proteins can undergo. Phosphorylation, methylation and acetylation all involve the addition of small chemical groups which affect function. Ubiquitylation involves the addition of the small peptide, ubiquitin, which targets proteins for degradation. Glycosylation is one of the more complex forms of PTM, […]
by Dr Gard Myrmel We have known for a while now that the symptoms of acute coronary syndromes can be different for women compared to men. Here, Dr Myrmel discusses how the differences between the sexes also extend to the prognostic value of circulating biomarkers in patients presenting with acute chest pain.
by PD Dr Angelika Hammerer-Lercher Measurement of cardiac-specific troponin I or T forms is part of the diagnostic pathway to rule in or rule out acute coronary syndromes, such as heart attack, as well as for prognostication of future cardiovascular disease. CLI chatted to Dr Angelika Hammerer-Lercher (Chief Physician and Director of Central Medical Laboratories, […]
by Dr Aleksandra Havelka Assays for NT-proBNP form a key part of diagnosing/ruling out, predicting and managing heart failure. CLI chatted to Dr Aleksandra Havelka (Gentian Diagnostics) to find out more about the challenges and limitations of measuring NT-proBNP concentrations, particularly the effects of glycosylation, and what developments are on the horizon to overcome these […]
by Dr Osaretin Emmanuel Asowata The detection of Pneumocystis jirovecii in immunocompromised patients is crucial for the treatment of Pneumocystis jirovecii pneumonia (PCP) and to prevent invasive infection. However, PCP can be challenging to diagnose clinically, as symptoms are non-specific. There are several laboratory methods that can be used to diagnose PCP and their advantages […]
Background Recent research suggests that the incidence of inflammatory bowel disease (IBD) in the UK is 1 in every 123 people, and that previously these numbers have been largely underestimated.
Colorectal cancer background and risk factors Colorectal (or bowel) cancer (CRC) is cancer anywhere in the colon (the large intestine) or the rectum.
If a patient has a suspected subarachnoid brain hemorrhage (SAH), time is of the essence. CLI chatted to Dr Suneesh Thilak (New Cross Hospital, Wolverhampton, UK) to find out about the role that imaging plays in diagnosis, securement and subsequent patient management of SAH.
Therapeutic drug monitoring is used for a number of reasons. The usual techniques include immunoassay and mass spectrometry, both of which have limitations. CLI chatted to Dr Pin Dong (University of York, York, UK) to discuss the potential for Fourier transform infrared spectroscopy to bridge the gap and provide high specificity measurements with a fast […]
January 2026
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