A new α1-microglobulin test has been developed for the determination of this excellent marker for the evaluation of renal tubular function. α1-microglobulin is also elevated in heavy metal poisoning, following renal colic, decreased glomerular filtration and renal disease associated with diabetes. After its secretion into the blood, α1-microglobulin is found in free form and in a wide variety of complexes. Only the free form of α1-microglobulin is filtered through the glomerulus and then reabsorbed by the proximal tubule of the nephron where it is degraded. In conditions with impaired tubular function, α1-microglobulin reabsorption decreases and its concentration in urine increases. This turbidimetry reagent is available in Manual and Automated Systems Reagents presentations.
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A complete range of kits for the testing of urinary proteins is available. Such tests are particularly useful from a diagnostic viewpoint, providing important information for the diagnosis of renal diseases, monitoring and differential analysis of proteinurias. All reagents are latex-based, ready-to-use and validated according to the international CLSI protocols. Within the range, urinary-Transferrin, urinary-Albumin (micro-albuminuria), and urinary-IgG, are of paramount importance. Albuminuria is one of the most important markers for damages to the endothelium. Pathological levels of urinary albumin (micro-albuminuria) are present in diabetes, hypertension, and during the early stages of preeclampsia. Transferrin and albumin together are pathognomonic of selective glomerular proteinuria. If the IgG levels rise the glomerular proteinuria becomes non selective. The accuracy guaranteed by the method allows correct calculation of the Cameron index (ratio between IgG clearance and transferrin clearance). The urinary proteins kits are available as both turbidimetry and nephelometry. The dedicated product lines include calibrators and controls whose assigned values are in accordance with International Scientific Committee’s guidelines. All urine testing products from Sclavo are available in specific formats and packaging developed for all Sclavo Systems (Sclavo Palio, Dirui, Konelab), Sclavo EasyNeph (nephelometry), in addition to the multi-purpose format. Along with specific proteins kits, the company offers a dedicated kit for testing total urinary proteins, highly sensitive to both tubular proteins, as well as Bence-Jones proteinuria, ensuring reliable and accurate results.

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The Simplexa HSV 1 & 2 direct molecular test running on the 3M Integrated Cycler is the first molecular test to be cleared by the FDA for the qualitative detection and differentiation of herpes simplex virus 1 (HSV-1) and herpes simplex virus 2 (HSV-2) in cerebrospinal fluid (CSF) from patients suspected of HSV central nervous system (CNS) infection, including encephalitis. The test uses a proprietary process that eliminates nucleic acid extraction, so clinicians can expect results within about an hour after providing a specimen for testing. Encephalitis is an inflammation of the brain oft en caused by the herpes simplex or other viruses. The Infectious Diseases Society of America (IDSA) recommends herpes simplex PCR testing on all CSF specimens in patients with encephalitis. HSV encephalitis occurs in all ages and during all seasons, with HSV-1 encephalitis more common in adults and HSV-2 encephalitis more common in newborn infants. Accurate determination of the virus-causing encephalitis can influence treatment decisions and outcomes. The moderate complexity categorization of the Simplexa HSV 1 & 2 Direct molecular test significantly broadens the potential clinical access to the technology. Moderate complexity laboratories, defined by the Clinical Laboratory Improvement Amendments (CLIA), include certain types of physician’s offices, community hospitals, health clinics and integrated delivery networks. These facilities typically lack the personnel and technology to perform high complexity molecular diagnostic tests. Since the test can be performed in these moderate complexity labs, patient results may be obtained readily to help speed therapeutic decisions. Simplexa tests, designed for use on the 3M Integrated Cycler, employ realtime polymerase chain reaction (PCR) technology to detect DNA or RNA in viruses, bacteria, and other analytes. Simplexa HSV 1 & 2 Direct showed strong performance in clinical studies, with 100% and 98% sensitivity for detection of HSV-1 and HSV-2 respectively. The test was CE-marked for distribution to more than 30 countries in Europe in November 2013.
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Perfect for LN2 freezing and long-term cryogenic freezer storage, the computer printable durable label for ultra low temperatures provides immediate permanent adhesion to all cyrovials, tubes and liquid straws stored down to -196ºC. Available in any format including ‘cap & tube’ label sets, they allow variable data (lot numbers, barcodes etc) to be added ‘in minutes’ straight from a standard laser, inkjet or thermal transfer printer, saving time and eliminating the risk of smudged or illegible handwritten data, providing reliable sample identification for liquid nitrogen storage.

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Biohit is introducing an improved liquid method for H. pylori detection from biopsy samples, the Helicobacter pylori UFT300 quick test. The detection is based on the detection of bacterial urease activity in gastric biopsy specimens. A gastric mucosa colonized by H. pylori is invariably inflamed, and can lead to atrophic gastritis, which has been linked with peptic ulcer and gastric cancer, two of the most important diseases of upper gastrointestinal tract. The quick test is easy to storage and perform and results are ready in a few minutes enabling diagnosis and reporting at the point of gastroscopy.
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