Siemens Healthineers announced recently the CE Mark and global commercial availability of its Atellica Solution – flexible, scalable, automation-ready immunoassay and chemistry analysers. The solution is now available across the globe in Europe, the United States, South America and Asia. The Atellica Solution is comprised of sample management, as well as immunoassay and chemistry analysers, and is an excellent fit for mid-and high-volume labs. It delivers unprecedented flexibility to adapt to changing testing needs and space constraints. The solution can combine up to 10 components into more than 300 customizable configurations – including linear, L and U shapes. It can operate as a stand-alone system or connect to Aptio Automation to provide a comprehensive, multidisciplinary testing solution that could include clinical chemistry, immunoassay, hemostasis, hematology, and plasma protein analysers. Further, with an immunoassay analyser that runs up to 440 tests per hour, the Atellica Solution delivers industry-leading productivity per square meter.
One key feature is the Atellica Magline Transport, the patented bi-directional, magnetic transport technology that is 10 times faster than conventional sample conveyors, and provides innovative and unique sample management capabilities. The transport technology, together with a multi-camera vision system, intelligent sample routing, and automatic quality control (QC) and calibration, give laboratories independent control over every individual sample – from routine to STAT – to deliver rapid, high quality patient results to clinicians. The Atellica Solution simplifies laboratory operations through intelligent sample management. It can process more than 30 different sample container types, including pediatric and tube-top sample cups that can be aspirated from the primary tube. Further, by using the same reagents and consumables across different analyser configurations, laboratories can streamline inventory and deliver consistent patient results no matter where patients are tested. Powering the Atellica Solution is a comprehensive menu of 170 assays, including 10-minute turnaround times for key cardiac, reproductive and thyroid tests, with 50 more assays in the pipeline. The immunoassay analyser features a patent-pending dual incubation ring design, temperature and humidity controls of the reaction environment, powerful magnets for relevant particle separation and robust washing protocols – all of which enable delivery of rapid, high precision results.
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Fecal calprotectin (fCAL) is the most important marker for in vitro diagnostic detection of gut inflammation. Immunological quantitation is well established and is used in the diagnostic work-up of inflammatory bowel diseases (IBD) and in the lifelong monitoring of these chronic conditions.
fCAL testing today requires a raised level of lab resources including stool sample handling, extraction and the use of traditional immunological testing methods, i.e. ELISA.
The BÜHLMANN fCAL turbo assay is a big step towards full automation. It reduces the time to result to 10 minutes and the total hands-on time significantly. It offers the possibility of random access on your existing clinical chemistry platform. Validated applications are available for many analysers.
The combination with the proprietary extraction device CALEX Cap for pre-analytical sample preparation simplifies and accelerates stool diagnostics significantly. The BÜHLMANN fCAL turbo utilizes the well-established standardization of the BÜHLMANN fCAL ELISA to provide reliability, comparability and continuity of measurements.

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The RX series test menu is world leading comprising an extensive range of high quality diagnostic reagents including routine chemistry, specific proteins, lipids, therapeutic drugs, drugs of abuse, antioxidants and diabetes testing.

Superior testing methodologies are available to extend your laboratory’s
testing capabilities. Placing precision, accuracy and reliability at the forefront, the RX series has 29 high performance and novel assays including direct HbA1c testing capabilities.

The RX series clinical chemistry analysers guarantee real cost savings through consolidation
of routine and specialised tests onto one single platform. With a range of semi-automated and automated analysers, the RX series offers versatility to suit the needs of all laboratory requirements.

For more information, visit www.randox.com/rxseries or to speak with your local Randox representative email therxseries@randox.com

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The new Nexera Mikros, a micro flowrate-compatible liquid chromatograph mass spectrometer, maintains the durability and operability of LC-MS systems while providing a significant increase in sensitivity. In pharmaceutical development, analysis occasionally has to be performed on trace amounts only of components in small blood samples. Examples include studies of the pharmacokinetics of new drug substances or their metabolism. In such cases, LC-MS systems compatible with nano flowrates have been utilized, in order to improve the efficiency of the intake of target components to the mass spectrometer. However, nano flowrate-compatible LC-MS systems often suffer from complications in terms of instrument operability and processing speed, such as a tendency for pipes to clog, difficulty in discovering liquid leaks, and the hours required for analysis of a single sample. The Nexera Mikros can accommodate a wide range of flowrates, from semi-micro flowrates (100 to 500 µL/min) which are often used for analysis in existing systems, to micro flowrates (1 to 10 µL/min). With this product, Shimadzu is contributing to improving productivity at pharmaceutical companies and clinical contract research organizations. Nexera Mikros achieves at least ten times the sensitivity for target compounds compared to standard LC-MS analysis. This is due to the LC-Mikros, a solvent delivery pump with a new control system to reduce pulsation and deliver a stable solvent flow even at low micro flowrates. In addition, positioning of the ionization interface has been optimized for more efficient sample introduction into the mass spectrometer.  Another specific feature, UF-Link, achieves both high-sensitivity analysis and improved operability. Microscopic gaps (dead volume) in the piping connectors lead to a decrease in sensitivity by causing peak dispersion. UF-Link, a connection mechanism between Shimadzu’s newly developed analytical column and the mass spectrometer, ensures high sensitivity and, at the same time, enables one-touch connection between the analytical column and the ionization interface for the mass spectrometer. In addition, UF-Link is compatible with connections between commonly used analytical columns and the ionization interface, so column selection is flexible to suit the target sample.

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