Two novel mutations in the PPIB gene cause a rare pedigree of osteogenesis imperfecta type IX Jiang Y, Pan J, Guo D, Zhang W, Xie J, Fang Z, Guo C, Fang Q, Jiang W, Guo Y. Clin Chim Acta 2017; doi: 10.1016/j.cca.2017.02.019. [Epub ahead of print] BACKGROUND: Osteogenesis imperfecta (OI) is a rare genetic skeletal […]
Human bocavirus 1 (HBoV1) causes respiratory tract infections in infants and children. Diagnosis of acute HBoV1 infections is challenging as viral DNA is frequently detected in asymptomatic controls and as co-finding with other viruses. Recently developed novel HBoV1 mRNA and antigen tests may improve the diagnosis of acute HBoV1 infections. by Juha M. Koskinen, Dr […]
The sequence diversity of the more than 150 currently recognized HRV genotypes poses challenges for the development of robust molecular methods that detect all genotypes with equal efficiency. Real-time reverse-transcription (RT)-PCR was compared to digital RT-PCR for quantification of HRV in clinical specimens when using type-specific and consensus primers and probes. by Dr Jane Kuypers […]
Viral diagnostic methods have evolved greatly in recent decades, with perhaps the most significant change being the widespread use of nucleic acid amplification tests (NAAT). The introduction of next-generation sequencing methods may see a further change in the landscape of infection diagnostics. Here we discuss some of the potential benefits and challenges with this approach. […]
Current molecular diagnostics of pathogens using traditional typing methods gives limited information for outbreak investigation. Next-generation sequencing determines the DNA sequence of a complete genome and reveals information on resistance and virulence. Furthermore, it allows typing with a higher discriminatory power, which is essential for outbreak and transmission investigations. by S. Rosema, Dr R. H. […]
Next-generation sequencing (NGS) is a new technology that can be used for broad detection of infectious pathogens and is rapidly becoming an essential platform in clinical laboratories. This review explores the feasibility and potential for the application of NGS in clinical and public health laboratories in terms of pathogenic virus detection and diagnostics. by Dr […]
Fifty-seven years ago the drug Enovid was approved for use as a female contraceptive in the USA, and most other developed nations quickly introduced similar formulations. Although this method of contraception has had enormous social impacts, allowing modern women greater access to higher education and remunerative employment, it has largely shifted the previously shared responsibility […]
MILFORD, Mass.–(BUSINESS WIRE)–Waters Corporation (NYSE:WAT) announced today that its fully-validated Waters® MassTrak™ Vitamin D Solution is now CE-marked in accordance with IVD Directive 98/79/EC for the quantitative measurement of 25(OH) D2 and D3 (25-OH-VitD) from human plasma and serum. The IVD LC-MS/MS system solution is a complete solution consisting of reagents and consumables, instrumentation, and software and support services […]
March 2026
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