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Author Archive for: 3wmedia
Entries by 3wmedia
‘Getting to zero’: first the good news
It is thirty years since the first diagnoses of AIDS were reported, since when, according to the most recent UNAids report, 25 million people have died from HIV-related causes and around 34 million people are currently living with the virus. However, as we enter the fourth decade of this devastating pandemic, there is certainly some […]
Recent progress in laboratory diagnosis of hereditary spherocytosis
Hereditary spherocytosis is an inherited haemolytic anaemia due to fragile red cells. This article gives a brief overview of the pathophysiology of this red cell disorder, and presents the key points on the different screening tests. by Dr May-Jean King Membrane structure of human red blood cell and associated defects The human red blood […]
Go with the flow? Use of flow cytometry for routine leukocyte differential
Recently several clinical laboratories have reported antibody cocktails to perform leukocyte differentiation for routine screening. Distinct advantages over microscopic leukocyte differentiation are the large number of counted cells (tens of thousands) and objective immunological definition of the cell types. Here we review the published protocols and their usefulness for a routine setting. by Dr G-J […]
Coagulation testing in a haematology lab: improving quality and efficiency
Over the last three years, the haematology laboratory at Sheikh Khalifa Medical City (SKMC) in Abu Dhabi has introduced two STA-R Evolution analysers to fully automate coagulation testing. CLI spoke to Dima Yassin, Senior Supervisor in the haematology lab at SKMC, to discover how the new system has improved quality and efficiency in her lab […]
Plague and its laboratory diagnosis
Plague is an acute bacterial infection in man caused by Yersinia pestis. Historically, it has resulted in devastating pandemics (Black Death) throughout the world with high mortality rates in which pneumonic man-to-man transmission followed the usual flea-to-man transmission [1]. Plague may have retreated over the past decades due to availability of effective antibiotics and intensive […]
Diagnosing diabetes mellitus in Asia using HbA1c
The prevalence of diabetes mellitus in Asia is rapidly increasing. Diabetes in Asia develops in a shorter time, at a younger age and in individuals with a lower body mass index than in the West. This review summarises the epidemiology and pathophysiology of diabetes in Asia as well as the difficulties and challenges in using […]
Oxidised low-density lipoprotein and oxLDL auto-antibodies: immunity modulates atherosclerosis
Oxidised LDL and antibodies to oxLDL are pathogenetically significant contributors in animal models of atherosclerosis, but the pathophysiological role of anti-oxLDL in humans, discussed in this article, remains to be clarified. by Prof. Dr Thomas Dschietzig Oxidised LDL It is currently generally accepted that oxidised low-density lipoprotein (oxLDL) plays a major pathogenetic role in initiating […]