Much like do-it-yourself (DIY) hardware stores, DIY or at-home diagnostic test kits possess both benefits and drawbacks. Making a decision is tricky. It may become even more so as a host of new kits arrive on the market, some of which are aimed at potentially deadly diseases like cancers. The growth in the DIY kit […]
The interest in newborn screening for lysosomal storage disorders (LSDs) has increased significantly due to newly developed enzyme replacement therapies, the need for early diagnosis, and advances in technical developments. However, testing for lysosomal storage disorders in newborn screening (NBS) raises many challenges for primary health care and their providers. The high frequency of late-onset […]
Increasingly sophisticated instruments and an expanding range of fluorochromes are making it possible to detect an increasing number of markers on a single cell. These advances are encouraging the wider adoption of polychromatic flow cytometry (PFC). This review looks at the benefits of PFC in clinical laboratories, and how to deal with the associated challenges. […]
Although globally prostate cancer (PCa) is the second most common cancer in men after lung cancer, and around one in six men in the West will eventually be diagnosed with the disease, the majority of these patients will die of unrelated causes. Thus PCa management should ideally not only involve diagnosis and provision of the […]
Nucleic acids, which are among the best signatures of disease and pathogens, have traditionally been measured in centralised screening facilities using expensive instruments. Such tests are seldom available on point-of-care (POC) testing platforms. Advancements in simple microfluidics, cellphones and low-cost devices, isothermal and other novel amplification techniques, and reagent stabilisation approaches are now making it […]
An electronic nose consists of an array of chemical sensors for the detection of volatile organic compounds and an algorithm for pattern recognition. Breath analysis with an electronic nose has a high diagnostic performance for atopic asthma that can be increased when combined with measurement of fractional exhaled nitric oxide. by Dr Paolo Montuschi Several […]
The ability to use genetic information to inform clinical decision making has emerged as a new tool in clinical practice, with noteworthy examples across many area of medicine. Cardiology and anticoagulation in particular have led the way in the translation of genetic findings into actionable clinical recommendations, spurred by the addition of genetically guided dosing […]
Chronic diseases are placing an increasingly heavy burden on the healthcare systems of both development and emerging countries. Together with renewed prevention strategies based on systematic and coordinated approaches, clinical laboratories will have an essential role to play with the advent of new biomarkers and the development of e-health systems. Chronic diseases are acknowledged to […]
There are many peer-reviewed papers covering autoimmunity, and it is frequently difficult for healthcare professionals to keep up with the literature. As a special service to our readers, CLI presents a few key literature abstracts from the clinical and scientific literature chosen by our editorial board as being particularly worthy of attention. Unraveling multiple MHC […]
The determination of autoantibodies is an important component in the diagnosis and differentiation of glomerular disease. Key analyses include antibodies against phospholipase A2 receptors (anti-PLA2R), the glomerular basement membrane (anti-GBM), neutrophil granulocyte cytoplasm (ANCA), double-stranded DNA (anti-dsDNA) and nucleosomes (ANuA). With these tests autoimmune reactions can be identified as causative factors of renal disease. by […]
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