Most of the colorectal cancer (CRC) screening programmes are based on fecal occult blood tests (FOBT). However, there is little information on the utility of FOBT in familial-risk CRC screening. A recently published study has evaluated the diagnostic accuracy of fecal immunochemical tests (FIT) for CRC and advanced colonic neoplasia detection in this population. by […]
Colorectal cancer is one of the commonest types of cancer and contributes significantly to cancer-related mortality. Recent research has focused on the identification, development, validation of sensitive and specific biomarkers to improve early diagnosis, to assess disease outcome, accurately predict response to therapy or monitor disease status after treatment. by Dr Caroline Coghlin and Professor […]
Colorectal cancer is one of the most prevalent types of cancer and is the fourth most common cause of cancer mortality. Identification of non-invasive biomarkers representative of disease heterogeneity is critical for diagnosis of early stage disease when the chance for cure is greatest. This article discusses two such biomarkers, brain-derived neurotrophic growth factor and […]
The diagnosis of acute kidney injury (AKI) is often hindered by the reliance on serum creatinine as a marker of kidney function, which can delay detection. Neutrophil gelatinase-associated lipocalin is a promising biomarker which increases within hours of kidney damage and could therefore improve the early diagnosis of AKI. by Dr Ashley Garner Clinical backgroundAcute […]
Fibroblast growth factor-23, a key regulator of phosphate and 1,25-dihydroxyvitamin D metabolism, appears to be an independent risk factor for mortality among chronic kidney disease patients. However, sample stability and poor analytical agreement between detection methods still need to be addressed for it to become a reliable biomarker. by Dr A. Kumar, Dr W. Herrington, […]
The kidneys play an important role in homeostasis, they regulate the amount of water and salts present in the body by filtering blood through the nephrons. Waste products are filtered out and eliminated from the body in the urine, which is made up of the excess water, salts and waste products. When the kidneys are […]
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