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Author Archive for: 3wmedia
Entries by 3wmedia
Viral hepatitis, the silent epidemic
Globally as many people (1.5 million) die each year from viral hepatitis as from HIV/AIDS, but whereas the latter viral disease attracts government and international action and funding, the former is comparatively neglected. It was for this reason that the WHO initiated World Hepatitis Day four years ago, to be observed on the 28th July […]
Liquid chromatography-tandem mass spectrometry: an introduction
The use of liquid chromatography-tandem mass spectrometry for clinical analysis is on the increase. This article describes what it is, why it can offer significant improvements over traditional assays and the limitations to be aware of. by Dr N. Homer IntroductionClinical biochemistry laboratories frequently use radioimmunoassays (RIA) and enzyme-linked immunosorbent assays (ELISA) for analysis of […]
Measuring cigarette smoke exposure: quantification of cotinine by LC-MS/MS
Smoking is a major cause of morbidity and mortality worldwide. The adverse health effects of chronic cigarette smoke exposure are widely known. Active smoking increases the risk of developing several pathologies including pulmonary disease, cardiovascular disease and cancer. Importantly, the sequelae of smoking also extend to non-smokers via frequent passive inhalation. Accurate measures of cigarette […]
Next-generation sequencing in clinical diagnostics and genomics research
The UK prime minister recently announced an investment package worth £300 million pounds for genomic research. This will include the sequencing of 100,000 genomes by 2017. The project, driven by Genomics England, will have a major impact on many areas of healthcare. Next-generation sequencing (NGS) technology is the method by which this sequencing will be […]
Next generation sequencing and metagenomics – fighting the scourge of antibiotic resistance
The emergence of drug-resistant bacteria is one of the biggest public health challenges today. In April 2014, the World Health Organization (WHO) warned that a “post-antibiotic era – in which common infections and minor injuries can kill” is far from “an apocalyptic fantasy” and has instead become “a very real possibility.” Two months later, the […]