Siemens Healthineers is launching to laboratories Sysmex’s CN-3000 and CN-6000 Hemostasis Systems for mid- and high-volume coagulation testing. The company offers a broad menu of both routine and specialty coagulation assays that help identify blood coagulation disorders that can be performed on the Sysmex CN-3000 and CN-6000 Systems. This includes the new Siemens Healthineers’s INNOVANCE Anti-Xa assay for heparin and direct oral anticoagulant testing (DOAC).

“Siemens Healthineers and Sysmex’s 25-year partnership in hemostasis enables us to deliver both quality and comprehensive hemostasis testing solutions to laboratories of all sizes across the world,” said Deepak Nath, PhD, President of Laboratory Diagnostics for Siemens Healthineers.

INNOVANCE Anti-Xa assay

Siemens Healthineers’s new INNOVANCE Anti-Xa assay is a ready-to-use, liquid-reagent heparin and DOAC assay. It delivers precise results without reagent reconstitution or waiting before use. The assay streamlines handling, reduces ordering complexity by enabling labs to test for heparin, as well as direct oral anticoagulants rivaroxaban and apixaban with one combined assay, and offers labs an economical testing solution for heparin and DOAC testing.

Atellica Process Manager

The Sysmex CN-3000 and CN-6000 Systems are designed to integrate with the Siemens Healthineers Atellica Data Manager and Aptio Automation to further streamline a hands-free workflow in the laboratory and to automate sample processing – including sample preparation as well as storage, refrigeration, and retrieval. With the ability to connect to Atellica Process Manager, labs can manage testing processes from a centralized location, while also gaining access to analytics to baseline and track key performance indicators such as turnaround time or problem samples. When connected to Atellica Data Manager, advanced algorithms can automatically determine the next steps in sample processing and routing helping labs to standardize testing protocols across multiple systems and locations.

• For more information, visit: Sysmex CN3000 and CN6000 systems

Waters Corporation has introduced the Waters™ SELECT SERIES™ MRT, a high-resolution mass spectrometer that combines Multi Reflecting Time-of-Flight (MRT) technology with both enhanced DESI and new MALDI imaging sources. Together, these technologies enable scientists to explore molecular structure and function through the precise identification and localization of individual molecules in samples, with a unique combination of speed, resolution, and mass accuracy.

For example, a scientist researching how an investigational oncology drug interacts with its intended target, such as a specific brain tumour receptor, can now do so much faster, at speeds up to 10Hz without compromising mass accuracy or resolution.

The SELECT SERIES MRT platform is the basis for the next generation of Waters’ high-resolution mass spectrometers. It is the first commercially available instrument of its kind that is capable of attaining 200,000 Full Width Half Maximum (FWHM) resolution and part-per-billion mass accuracy independent of scan speed. The superior performance of the SELECT SERIES MRT allows scientists to get the highest quality mass spectrometry data and information faster than any commercial mass spectrometer on the market todayⁱⁱ. The new Multi Reflecting Time-of-Flight technology features an extended flight path of almost 50 meters to give scientists a much clearer picture of structural information, including fine isotope structure.

“The Waters SELECT SERIES MRT opens the door to a greater understanding of molecules and their mechanisms of action in numerous scientific fields,” explained Dr. Udit Batra, CEO and President, Waters Corporation. “The clarity of images produced by this instrument can yield profoundly important molecular information to scientists in research areas such as targeted therapeutics, to provide insights and enable deep biological discoveries.”

DESI XS and MALDI imaging on a single MRT platform

The first application of the SELECT SERIES MRT unlocks the potential of MS imaging using DESI and MALDI ionization. DESI is a direct-from-sample, soft ionization technique performed under ambient environmental conditions, requiring no prior sample preparation. It provides imaging information about the biochemical distribution of small molecule drugs, lipids, and naturally occurring metabolites within a slice of tissue or on other sample surfaces after just a single measurement. Scientists are applying DESI to research breast and ovarian cancer, to study drug metabolism and pharmacokinetics (DMPK), to investigate the function of key metabolites in natural products in traditional medicines, and to get a closer look at the biotransformation of bacterial colonies after gene modifications.

Featuring a new high-performance sprayer and a heated transfer line, the advanced DESI XS source delivers new levels of usability, image clarity and sensitivity at high speed, bringing more accessible imaging to scientists through mass spectrometry data.

For scientists interested in conducting MALDI imaging experiments, the SELECT SERIES MRT is available with a newly designed MALDI source. MALDI is an ideal complementary technique for the imaging of biological molecules such as peptides and can visualize tissue sections at spatial resolutions of less than 10 microns. Taken together, the combination of imaging sources gives researchers the means to generate fine spatial information and morphological detail for biological samples and even visualize brain vasculature.

Customer shipments of the SELECT SERIES MRT are expected to begin in the fourth quarter of this year.

• For more information, visit: waters.com

CytoSMART Technologies has launched two new fluorescence live-cell imaging systems – the Lux3 FL Duo Kit and the Multi Lux3 FL. The CytoSMART Lux3 FL Duo Kit is a compact and cost-effective imaging system consisting of two fluorescence microscopes, designed for side-by-side comparison of cell cultures. The CytoSMART Multi Lux3 FL fluorescence live-cell imaging system consists of four compact Lux3 FL devices, equipped with two fluorescent (green and red) and one brightfield channel, and designed for long-term comparative studies and larger research teams.

Both systems operate from within a standard CO2-incubator or hypoxia chamber, allowing to analyse cells in their desired culture environment. Each system of two and four microscopes is connected to a single laptop, maximizing precious laboratory space. Monitoring and analysis of the running experiments can be done at any time from anywhere via the CytoSMART Cloud.

Jan-Willem van Bree, CTO at CytoSMART Technologies, said: “Last year we launched our first fluorescence live-cell imager, the CytoSMART Lux3 FL, and our customers were pleased with its performance and expanded research possibilities. This year we decided to scale up fluorescence live-cell imaging possibilities by launching two new advanced systems: the Lux3 FL Duo Kit and the Multi Lux3 FL. We always aim to develop and offer versatile and flexible solutions to life scientists. For example, the Multi Lux3 FL allows to run up to four individual imaging experiments simultaneously, without affecting the time-lapse imaging experiments of other lab members. This is a very convenient lab equipment for every research group that studies cell viability, co-culture models, single-cell migration, and many other cell-based assays can benefit from it.”

The main features and benefits of the CytoSMART fluorescence live-cell imaging systems include:

• Ideal for comparative studies– directly compare fluorescently-labeled cell cultures.
• Versatile – expand the number of variables you can examine using fluorescent labelling.
• Flexible – connect devices to the same laptop and control them individually.
• Incubator-friendly – study cells in their desired culture environment.
• Full remote access via the CytoSMART Cloud – no need to enter the lab to inspect cell cultures.
• Indispensable tool for long-term comparative studies – run up to four experiments simultaneously for days or weeks.
• Cost-effective and efficient solution – two or four fluorescence imaging devices connected to one laptop, including unlimited storage and unlimited number of user accounts.

• For more information, see the CytoSMART Lux3 FL Duo Kit
  and the CytoSMART Multi Lux3 FL.

Bio-Rad Laboratories has introduced three StarBright dyes designed for flow cytometry applications.

StarBright Violet 570, 670, and 710 dyes offer improved brightness and precise excitation and emission spectra, making them suitable for use in multicolour flow cytometry panels. Bio-Rad’s line of StarBright dyes offers researchers a range of fluorescent nanoparticles conjugated to highly validated flow antibodies.

“The new StarBright dyes offer improved brightness when compared to other available dyes at similar wavelengths, and they may be used with a wide range of flow cytometers,” said Mike Blundell, PhD, Bio-Rad Product Manager, Flow Cytometry, Life Science Group. “The unique profile of the dyes offers enhanced resolution of rare populations and low-density antigens as well as consistent and reproducible staining.”

Key benefits of StarBright dyes

• Compatible with new and existing protocols and suitable for use in multiplex panels
• Resistant to photobleaching and highly stable with minimal lot-to-lot variation
• Offer reliable Förster resonance energy transfer (FRET) for reproducible data
• Work with common staining buffers, including special polymer dye staining buffers, for easy integration into multicolour panels
• Ensure no loss of signal in fixation
• Offer narrow excitation and emission profiles for improved resolution in new and existing multicolour flow cytometry experiments

The StarBright Dyes are compatible with Bio-Rad’s ZE5 Cell Analyzer, S3e Cell Sorter, and other conventional and spectral flow cytometers.

• For more information, visit: www.bio-rad-antibodies.com/starbright