by James D. Peele, PhD The HEp-2 immunofluorescence assay (IFA) for ANA screening is excellent for ruling out many connective tissue diseases, but a positive result seldom translates into a clinically meaningful diagnosis. A new automated, efficient, enzyme immunoassay for ANA screening provides reliable, objective information that can be applied clinically with confidence.
The detection of liver/kidney/microsomal antibodies (LKM) is one of the most common analytical procedures performed in the autoimmunity laboratory. Several techniques can be currently adopted that allow the detection of LKM in patient serum, such as ELISA, line immunoassay or indirect immunofluorescence. Far from being outdated, indirect immunofluorescence is the major method used for the […]
The spectrum of autoimmune neurological syndromes has expanded substantially in the last fifteen years because of the discovery of novel anti-neuronal autoantibodies. Today’s autoantibody test portfolio includes over 32 different specificities associated with neurological diseases.
by Professor M. Herold Systemic autoimmune rheumatic diseases (SARD) are rare and difficult to diagnose. Antinuclear antibodies (ANAs) are one of the most important serological features in the diagnostic work-up of patients with SARD. However, up to 30% of healthy individuals tested are also positive for ANAs and in about 50% of these cases ANA […]
by Dr Petraki Munujos The anti-parietal cell antibodies show one of the most distinctive fluorescent patterns in the autoantibody screening by indirect immunofluorescence. Although these antibodies react with a well known target antigen (H+/K+ ATPase) solely present in the parietal cells of the gastric gland, the use of combined tissue sections in the same reaction […]
by Dr Jacqueline Gosink Differential allergy diagnostics using molecular components is a powerful tool for pinpointing the precise trigger of an allergy, enabling targeted immunotherapy and comprehensive risk assessment. Multiparameter systems streamline the diagnostic procedure by delivering a comprehensive and detailed patient profile in a single test. The multiplex EUROLINE DPA-Dx (defined partial allergen diagnostics) […]
by Dr Petraki Munujos The antinuclear antibodies (ANA) determination is one of the most commonly used techniques in the autoimmunity clinical laboratory. Far from being outdated, indirect immunofluorescence (IF) is a powerful laboratory tool not only for clinical diagnostics, but for disease follow-up and prognosis estimation as well. Unlike other more precise quantitative techniques, IF […]
by Carrie A. Chadwick The relationship between anti-glycolipid antibodies and peripheral neuropathies has for many years been studied by laboratory investigations because of the antibody-phenotype associations identified. This has led to the discovery of a number of peripheral nerve conditions affected by the presence of anti-glycolipid antibodies. This article describes some of the conditions associated […]
by L. Hughes, Dr A. Ballantyne, Dr C. Ford, Dr A. Ekbote and Prof. R. Gama Celiac disease (CD) is a common autoimmune gastrointestinal disease. Several serological tests are available to screen for CD. Since CD can present with fatigue, serological screening was incorporated into a ‘tired all the time’ testing profile available to general […]
by Dr Petraki Munujos The detection of anti-adrenal cortex antibodies, also known as 21-hydroxylase or 21-OH antibodies, is an aid in the diagnosis and treatment of autoimmune adrenalitis. Far from being outdated, indirect immunofluorescence is a major analytical procedure used in the autoimmune laboratory for the measurement of these autoantibodies. Several techniques can be currently […]
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