Histopathology is a crucial stage in the diagnosis of many diseases, particularly cancer staging and therapy management. Current challenges facing pathology are a shortage of pathologists and an increasing workload resulting from expanded screening programmes, increased test complexity and an increasing elderly population. Leeds Teaching Hospitals NHS Trust, UK, has a fully subspecialized diagnostic histopathology […]

by Dr Ruth Ayling Calprotectin is a protein derived from neutrophils and its presence in feces can be used as a surrogate marker of gastrointestinal inflammation. Measurement is useful to differentiate inflammatory bowel disorder (IBD) from functional bowel disease, which has similar clinical features but different etiology, and to manage patients with established IBD.

by Dr Jacqueline Gosink Tumour necrosis factor (TNF) inhibitors are increasingly used to treat chronic inflammatory bowel diseases, rheumatic diseases and psoriasis. Continuous drug level monitoring and administration interval adjustment accompanying the treatment with TNF inhibitors is the key to successful, individualized and targeted patient care. Concentrations of the TNF inhibitors adalimumab or infliximab can […]