The VACUETTE FC Mix Tube is specifically designed for reliable detection of diabetes and taking appropriate measures to combat the condition. The citrate/citric acid buffer ensures a quick stabilization of the blood sample. The glycolysis is catalysed and suppressed. Therefore, the blood sugar is held constantly at the in vivo value. Due to the sodium fluoride additive contained in the VACUETTE FC Mix Tube, inhibition is extended to 48 hours. Additionally, Na2-EDTA is included as an anticoagulant, which is effective due to complexation of Ca++. The almost full inhibition of glycolysis in the VACUETTE FC Mix Tube means that diagnosis is a much more reliable process than before. The stabilization is carried out in whole blood and therefore does not require immediate centrifugation. Unlike in tubes with liquid additives, the finely granulated additive does not cause a dilution effect. The breakdown of glucose (glycolysis) in venous blood samples is of great significance in pre-analytics, particularly in relation to the diagnosis of diabetes mellitus and gestational diabetes. To prevent imme-diate glycolysis in the event of delay between blood collection and measurement in the lab, test tubes should include a citrate/citric acid buffer as well as sodium fluoride (NaF). Read more
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BioMérieux has expanded its hepatitis panel, which already included diagnostic tests for hepatitis A, B and C, with the launch of two VIDAS hepatitis E tests. Hepatitis E is a widely underdiagnosed liver disease that is prevalent all over the world. It is caused by infection with hepatitis E virus which is mainly transmitted by the fecal-oral route, particularly through contaminated water and some undercooked meats. It is a serious pathology, since it can lead to fulminant or chronic hepatitis which can prove fatal if not properly treated. The number of infections with the hepatitis E virus is estimated at 20 million per year, including more than 3.3 million acute cases. bioMérieux is now able to offer laboratories and clinicians the first automated serological tests for anti-HEV in a single-test format to diagnose the pathology reliably and quickly (40 minutes). Read more
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As COVID-19 multiplied across the globe in early 2020, IVD companies raced to provide testing solutions. However, rapid development of diagnostic solutions led in some cases to compromised reagent quality, causing confusion and concern amongst clinicians and lab professionals.
With this background, Erba Mannheim committed to develop reliable and affordable solutions to SARS-CoV-2 testing. First out have been the ErbaLisa IgG and IgM antibody ELISA kits. These were developed and manufactured by Calbiotech, Erba group’s immunoassay center of excellence in California.
Quality and performance were top priorities. The IgG kits use Spike protein antigens to ensure clinical relevance and specificity, and IgM kits use a combination of Spike and Nucleocapsid antigens. Performance and accuracy were extensively validated by multiple studies in universities and public/private laboratories. With CE mark and pending US EUA authorization, ErbaLisa COVID-19 assays gained approval by strict global regulatory bodies including Brazil’s ANVISA and ICMR in India.
Our commitment is to make quality diagnostic solutions affordable to growing labs across all emerging markets in Asia, LATAM, MEA, Eastern Europe and Russia. We believe these products answer the immediate needs and are proud to be helping in the fight against COVID-19. Read more
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TRIMERO Diagnostics offers IVD CE marked Beta-2 Microglobulin (β2m) serum and urine assays for IMMAGE® series nephelometers.
The assays, for serum and urine samples, have been developed specifically for the Beckman Coulter’s IMMAGE® and IMMAGE® 800 Immunochemical Systems, using UDR particle-enhanced reagents.
In order to ensure lot to lot traceability, assays have been standardized to the to the 1st International Standard for Beta2 Microglobulin (code: B2M) of the WHO (World Health Organisation).
B2-microglobulin turbidimetric assays are also available for the most popular clinical chemistry analysers, for both urine and serum samples.
Other available assays for IMMAGE® nephelometers and turbidimetry include: KLoneus® Free Light Chains (FLC), Serum Amyloid A (SAA), IgD Immunoglobulins, Retinol Binding Protein (RBP) for serum and urine, Soluble Transferrin Receptor (sTfR), Hemopexin, Cystatin-C for serum and urine, A1-Microglobulin, Kappa and Lambda Light Chains for serum and urine, Complement C1q, Complement C5, Factor B (C3 Proactivator), C1 (Esterase) Inhibitor. Read more
https://clinlabint.com/wp-content/uploads/sites/2/2020/08/CLI_200408_doc_image_B2m-800.jpg8837233wmediahttps://clinlabint.com/wp-content/uploads/sites/2/2020/06/clinlab-logo.png3wmedia2020-08-26 09:16:522021-01-08 11:20:36Beta-2 Microglobulin (β2m), for serum and urine, on IMMAGE® series nephelometers
ioLight, creator of the world’s first high-resolution portable microscope, has now designed a new compact inverted microscope for cell culture observation in the lab. This very compact, lightweight and robust inverted microscope is even tough enough for use inside an incubator. The ioLight inverted microscope is just 170mm in size and sealed to protect the inner workings. This means it is perfectly suited to observing cell culture in a lab incubator without having to open the door. Cell development is monitored by an inverted microscope, with the lens underneath the petri dish looking upwards into the sample with illuminators both above and below the sample. Because the inverted microscope accommodates a petri dish, observation of cells and organisms can be achieved using standard laboratory procedures without having to prepare a slide sample. Through a simple Wi-Fi connection, the inverted microscope enables images to be stored on a tablet, mobile phone or laptop and shared instantly with collaborators anywhere. The ioLight inverted microscope uses both bright field and dark field illumination. Bright field mode illuminates high contrast samples from above, displaying them against a bright background. Dark field mode illuminates lower contrast or even transparent samples with scattered light, highlighting them against a dark background. This allows a wide range of samples to be imaged. The ioLight inverted microscope is a cost-effective and compact laboratory tool that is really simple to use. Users have the ability to view images on a mobile phone and because it is wireless they can leave the microscope inside an incubator so they do not have to disrupt the experimental conditions. Read more
Greiner Bio-One, a division of Greiner AG specializing in the development, production and distribution of high-quality plastic laboratory products, is proud to announce that it has changed its logo on its website and on all its existing social media channels. The new logos of all Greiner divisions were presented in September 2018 at the 150-years-anniversary gala in Kremsmünster (Austria) where the company is headquartered. The new Greiner Bio-One logo was developed with the aim of presenting Greiner AG visually more strongly as a group, without restricting the visual and perceived independence and autonomy of the divisions. Since this change is very time-consuming and many areas and content types are affected, it will take place in several stages over a period of up to five years.
www.gbo.com Read more
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Tuberculosis is one of the most prevalent infectious diseases worldwide, with 10 million new cases and an estimated 1.8 million fatalities per year according to the WHO. It is caused by pathogens of the Mycobacterium tuberculosis complex (MTBC). EUROIMMUN’s EURORealTime MTB test provides reliable direct detection of all bacteria of the MTBC in sputum, bronchoalveolar fluid and bronchial secretion by means of real-time polymerase chain reaction (real-time PCR).
The detection is based on three MTBC-specific target regions, encompassing a large number of genetic variants. The target sequences are amplified in a single multiplex PCR using highly specific primers and detected by real-time analytics. Numerous integrated controls ensure high result integrity.
The evaluation and interpretation of results is fully automated using the EURORealTime Analysis software and is thus highly standardised. The software also guides the user through the individual work steps, ensuring a simple and error-free test procedure. The entire process from sample to report release is IVD validated and CE registered.
The direct detection of tuberculosis pathogens complements other diagnostic methods such as microscopy and detection by culturing, which takes as long as 6 to 8 weeks. The PCRbased analysis thus supports early treatment and prevention of transmission.
For more information, visit: www.euroimmun.com Read more
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The Ziath range of CryzoTraq™ 2D-barcoded cryogenic tubes set a new standard for cryogenic storage of biological specimens at temperatures as low as -196°C.
Worldwide biobanks and biorepositories support many types of life science research including Genomics and Personalized Medicine. To ensure the integrity and viability of specimens stored in these sample storage facilities over long periods of time, the specimens are placed in a sterile storage tubes and immersed in vapor phase Liquid Nitrogen. Leak-free cryogenic tubes are therefore of utmost importance to ensure sample integrity. Produced using an innovative 2-stage injection moulding process the caps on CryzoTraq tubes deliver outstanding leak resistance. This high integrity closure on CryzoTraq tubes ensures that the sample cannot leak out and conversely that no contaminants can enter the tube. This is vitally important because if the specimen is contaminated, it is rendered useless for further research.
To ensure full sample traceability, all CryzoTraq tubes have a 2D datamatrix barcode inserted in the base of the tube. The insert is secured in place by the use of ultrasound to weld it into place. During this manufacturing process, a linear barcode is printed onto the side of the tube first, and the 2D code is automatically generated from the linear barcode therefore ensuring the two barcodes will always be the same with no errors.
Available in 2 ml and 5 ml volumes, CryzoTraq tubes are certified free from DNA, DNase, RNase, pyrogens and ATP. Each lot is sterilized with electron beam radiation. CryzoTraq tubes are manufactured from medical grade polypropylene and the caps from medical grade polyethylene.
To enable fast and precise decoding of the 2D-barcodes on CryzoTraq tubes, Ziath offers its high performance DataPaq™ Multirack and Cube scanners.
For more information, visit: www.ziath.com/index.php/products/tubes/ cryzotraq-tubes-and-racks Read more
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Tempus600 Quantit is the latest addition to the innovative Tempus600 product range – a dedicated point-to-point system securing fast and predictable turnaround time for blood samples. Quantit caters for the need to dispatch several samples at the same time without any packaging. The system is characterized by a minimalistic, user-friendly and intuitive design, facilitating easy dispatching of blood samples. Up to 25 samples can be placed simultaneously in the drawer and the system will send them one-by-one with a speed of up to 10 m/sec. The quick transportation time results in a total turnaround time of 31 minutes for blood samples. Quantit handles up to 1050 sample tubes per hour. An optional urgency module allows staff to access the system at any time and manually place priority samples for immediate processing. The Tempus600 Quantit delivers blood samples to fully automated, semi-automated or manual laboratories. The system is installed in existing hospitals in just 2 weeks. Read more
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Provides high efficiency, saves space and enables multi-sample processing / Customer- and application-specific solution / Time-saving by simplified, fast operation
Shimadzu, one of the world leaders in analytical instrumentation, has announced the release of its new Nexera Prep Series Preparative Purification Liquid Chromatograph (LC). “Preparative HPLC” is a process in which specific substances are separated and purified from samples. The new Nexera Prep Series provides better prep processes for extraction of functional and impurity components, as well as purification of target compounds in the pharmaceutical, chemical and food industries. This product dramatically improves productivity via flexible scalability and an efficient, user friendly preparative workflow. Customer- and application-specific solution The Nexera Prep Series consists of multiple related products with the LC units as the core. Users select a pump, autosampler and detector to build a system according to the purpose of the preparative work. Systems can be configured using related products such as the LH-40 Liquid Handler, FRC-40 Fraction Collector, Shim-pack Scepter LC Column for Analysis and Preparative Work, and Column Hub.
Preparative purification is generally performed following a multi-step workflow, which requires experience and time:
Selection of system configuration and preparative column size based on the amount
of purified sample or injection volume required
Selection of fraction collector and container size according to the intended purpose
Investigation of separation conditions in analytical scale
Optimization of preparative LC conditions
Confirmation of the purity of collected fractions
In addition to these steps, in some cases salts need to be removed or solvent needs to be evaporated after purification, requiring additional time and effort. Time-saving by simplified, fast operation The Nexera Prep Series reduces the time spent on examining conditions using the software’s fractionation simulation function. It also enables simplified, fast operation in transition from analytical to preparative scale, with a column portfolio that covers a wide range of sizes. Furthermore, Shimadzu’s unique UFPLC (Ultra Fast Preparative and Purification LC) high-purity purification system reduces the time required for powderization via the elution of desalted target components with an organic solvent. This product satisfies a number of user demands, such as efficient desalting and powderization, multi-sample and multi-fraction analysis, effective separation at low cost and the ability to check the purity.
Specifically, the product can be used for the following purposes:
Concentration and purification of immunosuppressive agents
Preparative work for impurities in degradants of medicinal agents
Separation and purification of functional components from natural materials
Consecutive analysis to separate and purify polymers and their additives and confirm the purity
The Nexera Prep Purification LC System provides new features to simplify the preparative workflow:
Reduces the time required for investigating conditions With the fractionation simulation function of the LabSolutions analysis software and the Shim-pack Scepter LC column for analytical and preparative HPLC, which offers excellent scalability, the product reduces the time required for investigating preparative work conditions. The LH-40 Liquid Handler can be used both, as a fraction collector and as an autosampler for large-volume injection with liquid surface detection function (option). It also enables seamless purity checks through re-injection (option) of collected sample after fractionation. Additional features including a sample rescue protocol to collect the sample from the system if an error occurs after an injection, a function to automatically extract the target peaks only, and high-purity preparative purification using detector signals from up to four channels, enable more efficient operation.
UFPLC high-purity purification system Samples must be in a state of concentrated solution or dry powder to analyze their structure or to store them. When a solution contains water, it takes time to dry and concentrate it. When a salt such as trifluoroacetate has been added, it remains in the crystal of the compound, lowering the purity and negatively influencing pharmacokinetic studies and other tests. Shimadzu’s unique, automated UFPLC purification system introduces fractions containing the target compound, separated in a preparative column, into a trap column. Salt and water are then washed off and elution is induced with an organic solvent. This reduces the time required for drying, providing compounds with a high level of purity.
Flexible system scalability Both the LH-40 Liquid Handler and FRC-40 Fraction Collector are designed to save installation space, requiring only half the space of other vendors’ products. They support containers of a form and size suitable for the recovered quantity. Up to six units can be connected, so up to 3240 10 mm diameter test tubes can be placed. Using the new Column Hub, up to six columns and four flow-line switching valves can be installed, enabling the compact configuration of various systems.
Web summary Shimadzu has announced the release of its new Nexera Prep Series Preparative Purification Liquid Chromatograph (LC). It provides better prep processes for extraction of target compounds and impurities during drug discovery in the pharmaceutical industry and purification of functional components in the chemical and food industries. This product improves productivity dramatically via efficient preparative workflows using LC or LC-MS methodology.
Web link: www.shimadzu.eu/nexera-prep Read more
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