Covering a total of 15 commonly tested and esoteric cancer antigens and tumour markers, the Acusera multi-analyte liquid tumour marker control is ready to use. The material is highly convenient and easy for laboratory staff. The addition of assayed target values enables laboratories to effectively monitor measurements with both accuracy and precision. The liquid stable nature not only eliminates the need for reconstitution but reduces the amount of human handling necessary and allows the material to be shipped and stored conveniently at 2-8oC. The serum is 100% human in origin providing a matrix similar to the patient sample but also reducing antibody interference and the possibility of control values shifting after changing reagent batch. Three distinct and clinically significant levels of control are available with analytes present at desirable levels. The convenient 6 x 3mL pack size and refrigerated open vial stability of 30 days for all analytes helps to increase laboratory efficiency while keeping waste and costs to a minimum. As a true third party control laboratories can use it to independently assess the performance of their tumour marker testing. Fully assayed, instrument specific target values are generated via a number of external laboratories and are provided for many common clinical chemistry and immunoassay systems. The control is compatible for use with Acusera 24.7, a web based inter-laboratory data management programme. With 24-7 users benefit from the company’s extensive range of data management tools and gain access to peer group data from thousands of laboratories worldwide. The programme uniquely updates peer group data every 24 hours giving laboratories access to the most up to date information available.
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Cryogenic sample storage requires tubes that can withstand the pressures of being frozen in liquid nitrogen and thawed again. Providing biological sample storage in temperatures as low as -196oC, the Cryo- Clear vials feature a unique screw cap that is co-moulded with thermoplastic elastomer eliminating the need for silicone o-rings. This special process prevents the risk of sample contamination and provides the purest and most leak-resistant vial available. The tubes are certified 95kPA to provide a 100% leak-proof seal. Each production lot is certified by an independent laboratory to be free of human DNA, DNase, RNase, Pyrogens and ATP, and the vials are manufactured, assembled and packaged in a Class 7 clean room and never exposed to outside contaminants. Each tube is printed with a unique 128-format barcode for automated data collection, accurate sample inventory and to hide the identity of the sample. The vials are available with internal and external threads and with round or self-standing interlocking bottoms.
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Kidney injury molecule-1 (Kim-1) has been qualified by the Food and Drug Administration and European Medicines Agency as a highly sensitive and specific urinary biomarker to monitor drug-induced kidney injury in preclinical studies and on a case-by-case basis in clinical trials. The urinary Kim-1 band intensity using the Kim-1 dipstick significantly correlated with levels of Kim-1 as measured by a microbead-based assay, histopathological damage, and immunohistochemical assessment of renal Kim-1 in a dose- and time-dependent manner. Kim-1 was detected following kidney injury induced in rats by cadmium, gentamicin, or bilateral renal ischaemia/reperfusion. In humans, the urinary KIM-1 band intensity was significantly greater in urine from patients with acute kidney injury than in urine from healthy volunteers. The KIM-1 dipstick also enabled temporal evaluation of kidney injury and recovery in two patients who developed postoperative acute kidney injury following cytoreductive surgery for malignant mesothelioma with intraoperative local cisplatin administration.
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The MDF-U76V ultra-low freezer combines improved cooling performance with outstanding energy efficiency. The advantages include greater security for precious research or clinical samples, as well as significantly lower running costs and added environmental benefits. This latest -86ºC VIP upright freezer has been specifically designed to meet the growing demand for energy savings, without in any way compromising freezer performance. In fact, cooling efficiency, insulation characteristics and door-open recovery times have all been enhanced via a capillary tube heat exchanger, next-generation VIP PLUS insulation, and the Cool Safe compressor. As a result, greater temperature uniformity throughout the freezer and faster temperature pull-down contribute to industry-leading sample security. The advanced new capillary tube heat exchanger significantly increases the overall efficiency of the freezer. By optimising the available heat exchange areas, system reliability is also increased and energy consumption is cut. In addition to helping minimise energy use, the high performance patented vacuum panels together with high-density foam insulation enable the freezers to provide up to 30 per cent more storage capacity than a conventionally insulated freezer, saving valuable lab space. An optional water-cooled condenser is also available. This enables laboratories with a chilled re-circulating water system to reduce the requirement for air conditioning within the freezer facility, reuse heat energy elsewhere and achieve even greater savings.
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Designed for diagnostic assays, the Whatman FF High Performance (HP) membrane enables fast, razor-sharp line separation and highly reproducible results for the detection of target molecules in liquids such as water, urine, blood and saliva. Th e target molecules may include drugs, hormones, proteins, antibodies, nucleic acids, whole bacteria and viruses. Th e membrane is suitable for use in lateral fl ow assay manufacture as it provides improved reliability and rapid results. Production using an innovative casting method yields a uniform, new powderfree surface that delivers a coeffi cient of variation in capillary rise of < 10 %. Both the intra- and inter- lot consistency was tested through analysis of over 1000 samples giving a low coeffi cient of variation. Th is excellent reproducibility improves the consistency of assays and off ers a more reliable limit of detection, which in turn reduces the costs of assay optimization for researchers. Th ree FF HP membranes are available with diff erent capillary rise times (wicking rate), allowing researchers to choose the most suitable membrane for their assay. Read more