Designed for the measurement of MxA protein in human whole blood, an innovative ELISA based on the use of patented monoclonal antibodies and a special buffer to extract the cytoplasmic MxA protein is suitable for the monitoring of IFN-β therapy in multiple sclerosis patients and for viral infection recognition. Human Myxovirus protein A is induced exclusively by IFN-α and IFN-β. Since direct measurement of the IFN levels in plasma is difficult, MxA may be useful as a marker distinguishing viral disease from bacterial infection or from acute graft-versus-host disease after allogenic stem cell transplantation. Neutralizing antibodies may develop during the IFN-β therapy of multiple sclerosis and lead to loss of drug bioactivity. The IFN-β-inducible MxA protein is an ideal marker of IFN-β bioavailability, capable of discriminating between biologically responsive and non-responsive patients. The BioVendor assay meets all the requirements for routine clinical use in manual mode as well as on open ELISA robotic systems.
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The new AB SCIEX IVD-MS analyser provides a combination of the high sensitivity and selectivity of mass spectrometry (MS) technology and the molecular separation power of liquid chromatography (LC) with a technicianfriendly, intuitive interface. The new SCIEX ClearCore MD Software provides streamlined data processing, reporting and review functionality. This will help make the adoption of LC/MS/MS for routine analysis significantly easier. The ClearCore software enables quantitation and data exploration without the need for additional software packages. It provides simple method development tools with separate LC and MS method editors. It also provides customizable access to modules based on user security levels, including routine users, method developers, data reviewers and administrators, so personnel is only able to access approved modules. This software drives the workflow that utilizes the power of the analyzer. The new IVD-MS analyser joins the company’s growing line of in vitro diagnostic devices for certain European countries, including the AB SCIEX 3200MD CE-IVD series of MS systems. The intended use of this CE marked, regulatory-compliant device is to identify inorganic or organic compounds in human specimens for clinical use, providing routine diagnostic testing laboratories in certain countries in Europe with the ability to quantitate multiple trace level compounds in a single analysis with high confidence in the results.
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The Randox LDL cholesterol assay utilises the clearance method for the accurate diagnosis of patient samples. The advanced reagent formula enables rapid clearance of all non-LDL lipoproteins from a sample, enabling the diagnosis of LDL cholesterol only. Furthermore, patient samples where diabetes, liver disease or high triglyceride levels are a concern can be accurately measured using the Randox LDL cholesterol assay.

The Friedewald calculation is often used in LDL measurement however the accuracy of this method is inadequate due to its dependency on “normal” triglyceride levels. At high levels of triglycerides a large number of samples are misclassified using the Friedewald calculation leading to significant discrepancies between calculated LDL cholesterol and the true value. The Randox LDL clearance method eliminates this problem and ensures truly accurate results are produced.

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Avantor™ Performance Materials offers BeneSphera™ brand hematology analysers for human or veterinary applications, available in select markets* in Europe and Asia.
Together with J.T.Baker® brand reagent products from Avantor, BeneSphera™ brand hematology analysers can help your testing operation achieve optimal performance.
BeneSphera™ brand hematology analysers from Avantor enable you to perform  in vitro examination of specimens derived from the human body. These reliable, easy-to-use analysers are capable of monitoring a 3-part differential population.
Avantor also offers the BeneSphera™ brand 3-part differential VET hematology analyser –  capable of analyzing specimens from eleven species of animals.
Both analysers have a throughput of 60 samples per hour and only need 9.6 µL of whole blood sample volume to provide twenty parameters and three histograms.

Visit: www.avantormaterials.com/Diagnostics-Global for more information
or send us an email: avantor.emea@avantormaterials.com

*For availability and more information, contact your local Avantor Account Representative or distributor.
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Now introduced is a two-component immunoturbidimetric reagent for the determination of hemoglobin A1c on general chemistry analysers. The methodology uses a highly specific monoclonal antibody to hemoglobin A1c to generate increased turbidity in the presence of hemoglobin A1c. With the single R2 component stabilized, mixing two separate R2 components is no longer necessary. This single R2 component provides the consumer with unsurpassed ease of use. Automated hemolysis can be performed on many different chemistry analyzers, providing a totally automated test system. The simple competitive binding principle used in this hemoglobin A1c method provides direct determination of hemoglobin A1c. This eliminates the need to perform a total hemoglobin assay, providing greater accuracy and precision by removing the additive error from performing two assays to achieve a single result. The method can be applied to most general chemistry analysers. This eliminates the need for a dedicated hemoglobin A1c analyser, reducing capital expenditures and labour costs while increasing efficiency and productivity. These hemoglobin A1c reagents are liquid-stable and have been shown to be accurate and precise. Pointe Scientific’s hemoglobin A1c calibrators are referenced to IFCC materials and are also NGSP certified. Hemoglobin A1c controls are also available for use with the new hemoglobin A1c reagent.
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