Next-generation sequencing (NGS) is a new technology that can be used for broad detection of infectious pathogens and is rapidly becoming an essential platform in clinical laboratories. This review explores the feasibility and potential for the application of NGS in clinical and public health laboratories in terms of pathogenic virus detection and diagnostics. by Dr […]
Current molecular diagnostics of pathogens using traditional typing methods gives limited information for outbreak investigation. Next-generation sequencing determines the DNA sequence of a complete genome and reveals information on resistance and virulence. Furthermore, it allows typing with a higher discriminatory power, which is essential for outbreak and transmission investigations. by S. Rosema, Dr R. H. […]
Viral diagnostic methods have evolved greatly in recent decades, with perhaps the most significant change being the widespread use of nucleic acid amplification tests (NAAT). The introduction of next-generation sequencing methods may see a further change in the landscape of infection diagnostics. Here we discuss some of the potential benefits and challenges with this approach. […]
The sequence diversity of the more than 150 currently recognized HRV genotypes poses challenges for the development of robust molecular methods that detect all genotypes with equal efficiency. Real-time reverse-transcription (RT)-PCR was compared to digital RT-PCR for quantification of HRV in clinical specimens when using type-specific and consensus primers and probes. by Dr Jane Kuypers […]
Human bocavirus 1 (HBoV1) causes respiratory tract infections in infants and children. Diagnosis of acute HBoV1 infections is challenging as viral DNA is frequently detected in asymptomatic controls and as co-finding with other viruses. Recently developed novel HBoV1 mRNA and antigen tests may improve the diagnosis of acute HBoV1 infections. by Juha M. Koskinen, Dr […]
Two novel mutations in the PPIB gene cause a rare pedigree of osteogenesis imperfecta type IX Jiang Y, Pan J, Guo D, Zhang W, Xie J, Fang Z, Guo C, Fang Q, Jiang W, Guo Y. Clin Chim Acta 2017; doi: 10.1016/j.cca.2017.02.019. [Epub ahead of print] BACKGROUND: Osteogenesis imperfecta (OI) is a rare genetic skeletal […]
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