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Author Archive for: 3wmedia
Entries by 3wmedia
The effects of tobacco smoke: first the bad news
It was over sixty years ago that Sir Richard Doll’s pioneering work first demonstrated a causal link between tobacco smoking and an increased risk of lung cancer. The lessons drawn from it have undoubtedly saved millions of lives over the years, but it is disappointing that according to the recently published European cancer mortality predictions […]
Detection of circulating tumour cells from peripheral blood of breast cancer patients via real-time PCR
As the appearance of circulating tumour cells in the peripheral blood of breast cancer patients is linked to a worse prognosis for overall survival and treatment efficiency, their detection and characterization will have a high impact on cancer therapy, opening roads to a more personalized treatment. by Dr U. Andergassen, Dr A. C. Kölbl, Prof. […]
Tissue biomarkers of breast cancer: implications for prognosis
Better tissue biomarkers are needed to improve diagnosis and prognosis, guide molecularly targeted therapy, and monitor activity and therapeutic response across many cancers. Proteomics methods, based on mass spectrometry, hold great promise for the discovery of novel biomarkers that might form the foundation of a new clinical test. This review will focus on potential tissue […]
Genetic diagnostics in pediatric hearing loss
Hearing impairment in newborn children is one of the most frequent forms of sensorineural disorders, affecting 1 in 1000 infants. In half of the cases the hearing loss has a genetic basis, and over 70 genes have been identified so far, making hearing loss genetically exceptionally heterogeneous. Early detection in newborns, in combination with a […]
Molecular techniques used in the diagnosis of cutaneous lymphoma
Cutaneous lymphomas are a heterogenic group of conditions often difficult to diagnose. The diagnosis requires careful correlation between clinical presentation pathology and molecular analysis. Molecular analysis includes inmunophenotyping, clonality assays and rarely chromosomal analysis. The importance of molecular analysis hinges on two main reasons: firstly to confirm the diagnosis and secondly to further characterize the […]
DNA microarrays for SNP profiling in thrombosis and hemochromatosis
Specialized diagnostic DNA microarrays provide fast and reliable determination of factor V and factor II gene mutations associated with thrombosis or HFE gene defects linked to hereditary hemochromatosis. The simple microarray procedure includes fully automated data analysis and can be performed on whole blood samples, circumventing the need for preanalytical DNA isolation. Patient genotyping aids […]
RND efflux pumps in P. aeruginosa: an underestimated resistance mechanism
An adequate initial antibiotic therapy is a key determinant of therapeutic success in Pseudomonas aeruginosa – infected patients. Antibiotic efflux is an underestimated resistance mechanism because it may occur in strains categorized as susceptible. It is rarely or not at all diagnosed in routine laboratories and often masked by high-level resistance mechanisms. by Dr Laetitia […]
Prokaryotic-expressed recombinant nucleocapsid protein for the detection of coronavirus infection
The early diagnosis of common colds caused by coronavirus is a crucial step in preventing the recurrence of a global outbreak. The goals of this article are to discuss a prokaryotic-expressed recombinant nucleocapsid protein used in the development of a sensitive diagnostic assay for the diagnosis of human coronavirus infection. by Dr Ming-Hon Hou An […]