Following the trend in the US, pressure is mounting on big European hospital labs to consolidate their operations and boost workflow performances while at the same time making better use of their staff. The Aptio Automation system from Siemens Healthcare Diagnostics goes a long way to fulfill these objectives. Here we take a look at […]
Rapid diagnostic testing enables life-saving scale up of HIV diagnosis but is vulnerable to false positive results. Confirmation testing can be impractical or cost prohibitive in resource-limited settings. Retesting a diluted blood sample is evaluated and proposed, at a proof of concept level, as a simple cost-effective HIV confirmation methodology. by Derryck Klarkowski and Dr […]
To reduce the window period for HIV-1 infection, a method for detecting trace amounts of HIV-1 p24 in blood is needed. We developed a simple de novo ultrasensitive colorimetric ELISA by adding a thio-NAD cycling solution to the standard ELISA. The limit of detection for p24 was 0.005 IU (i.e. attomoles) per assay by the […]
When founding the company GONOTEC GmbH in 1979, electronics engineer Harald Göritz and chemist Klaus Noack could not possibly imagine that their target to develop, produce and market analytical measuring instruments for medical and chemical application would be as successful as it turned out to be. Both founders of the company could already look back […]
Alzheimer’s disease (AD) is the most common cause of dementia. It is characterized by accumulation of β-amyloid (Aβ) peptides and tau proteins, loss of neurons and cognitive decline. It is difficult to diagnose AD in the early stages by clinical examination. Cerebrospinal fluid (CSF) biomarkers can be used to overcome this and could be useful […]
The two aims of this article are to review some current methods of early diagnosis of Alzheimer’s disease (AD) and to discuss a new integration method proposed in Kong et al. [1]. We focus on how to combine the whole genome single nucleotide polymorphism (SNP) data and high-dimensional whole-brain imaging data to offer predictive values […]
Biological markers (biomarkers) for Alzheimer’s disease (AD) assess risk as well as the presence and progression of the disease. AD biomarkers are derived from cerebrospinal fluid (CSF) and plasma. Some biomarkers have been evaluated as part of regulatory guideline documents, often in Phase II drug development trials establishing safety and tolerance. Large-scale multi-centre trials are […]
An eventually fatal neurodegenerative condition characterized by progressive loss of memory and cognition, Alzheimer’s disease (AD) is the major cause of dementia globally. It is estimated that worldwide around 44 million people are suffering from dementia; this has been predicted to triple by 2050 as the population ages, since AD increases exponentially after the age […]
March 2026
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