The current prognostic staging of colorectal cancer (CRC) by the tumour, node, metastasis method, alongside the minimal core data set, provides good prognostic information for patient populations but is less accurate for the individual. Reporting of additional histopathological features can improve individualized prognostic staging, but manual microscopic surveillance often results in observer variability and there […]
Interactions of neoplastic cells with each other and the microenvironment are complex. The main factors contributing to intratumoral heterogeneity may be reflected in biomarker expression. The aim is to investigate the spatial intratumoral heterogeneity of Ki-67 immunostains in whole sections of pancreatic neuroendocrine neoplasms. The extent and range of heterogeneity has potential as a prognostic […]
When Dr Margaret Chan, Director-General of WHO, stated that the health risks for both participants and spectators at the Rio Olympic games were “low and manageable” she was referring to possible exposure to Zika virus. But the other major health concern raised was the quality of the water, particularly for the one to two thousand […]
Lp(a) is a complex macromolecule synthesized in the liver, it presents similarities with Low Density Lipoprotein (LDL) as it possesses a cholesterol-phospholipid core and a closely associated protein, apoB100. Lp(a) differs however from LDL in that each lipoprotein particle contains one copy of the glycoprotein apolipoprotein (a) [apo (a)] covalently bound to apoB100 by a […]
This article describes the experiences of the Virology Department at Toulouse University Hospital, France, in the evaluation of a new, fully automated molecular diagnostics system for the quantitative determination of nucleic acid targets, such as cytomegalovirus (CMV) DNA and human immunodeficiency virus type 1 (HIV-1) RNA. by Prof. Jacques Izopet The 3000-bed Toulouse University Hospital […]
Prednisolone is an attractive once-daily option to treat adrenal insufficiency. Its prior association to osteoporosis and diabetes is possibly due to widespread over-replacement. With the availability of an ultra-performance liquid-chromatography tandem mass spectrometry (UPLC-MS/MS) method to detect serum concentrations and guide treatment, we can assess the true effects of long-term low-dose prednisolone therapy. by Dr […]
March 2026
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