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Author Archive for: 3wmedia
Entries by 3wmedia
Chromosomal rearrangement detection in lymphomas: digital FISH analysis
Detection of chromosomal rearrangements using fluorescence in situ hybridization (FISH) in lymphomas is an important diagnostic measure for treating this aggressive tumour type. This article aims to describe the recent advancements in the technology. by Dr Michael Liew, Leslie Rowe and Prof. Mohamed E. Salama BackgroundLymphomas are cancers that affect cells of the lymphatic or […]
Is fully integrated LC-MS/MS the future for the routine clinical lab?
Liquid chromatography-mass spectrometry (LC-MS/MS) is an analytical chemistry technique that combines the physio-chemical separation capabilities of liquid chromatography (via conventional chromatography within a column) with the analytic power of mass spectrometry. It allows the user to properly ascertain the individual mass/charge ratio of analytes present in a chromatographic peak. The high throughput capabilities of this […]
Measurement of serum folate vitamers by LC-MS/MS
The use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) to measure serum folate has been recommended for population monitoring as it allows a more accurate and reproducible measurement than the commonly used protein binding assays. The ability to differentiate between endogenous folate vitamers and folic acid makes LC-MS/MS an extremely valuable tool, not least due to […]
Inductively coupled plasma mass spectrometry: the future of sweat analysis?
Sweat chloride is the gold standard diagnostic test for cystic fibrosis (CF) offering direct measurement of cystic fibrosis transmembrane conductance regulator (CFTR) protein function. Current methods are labour-intensive, complex, time-consuming and require relatively large sample volumes. Inductively coupled plasma mass spectrometry (ICP-MS) is an emerging technology capable of providing rapid and accurate sweat chloride concentrations […]
UPLC-MS/MS measurement of prednisolone in adrenal insufficiency
Prednisolone is an attractive once-daily option to treat adrenal insufficiency. Its prior association to osteoporosis and diabetes is possibly due to widespread over-replacement. With the availability of an ultra-performance liquid-chromatography tandem mass spectrometry (UPLC-MS/MS) method to detect serum concentrations and guide treatment, we can assess the true effects of long-term low-dose prednisolone therapy. by Dr […]
Ensuring high quality viral load results, reduced turnaround times and enhanced laboratory workflows
This article describes the experiences of the Virology Department at Toulouse University Hospital, France, in the evaluation of a new, fully automated molecular diagnostics system for the quantitative determination of nucleic acid targets, such as cytomegalovirus (CMV) DNA and human immunodeficiency virus type 1 (HIV-1) RNA. by Prof. Jacques Izopet The 3000-bed Toulouse University Hospital […]
Assay kit for the assessment of Lp(a) levels in serum or plasma with minimum apo (a) size related bias
Lp(a) is a complex macromolecule synthesized in the liver, it presents similarities with Low Density Lipoprotein (LDL) as it possesses a cholesterol-phospholipid core and a closely associated protein, apoB100. Lp(a) differs however from LDL in that each lipoprotein particle contains one copy of the glycoprotein apolipoprotein (a) [apo (a)] covalently bound to apoB100 by a […]
Rio 2016: will there be health repercussions?
When Dr Margaret Chan, Director-General of WHO, stated that the health risks for both participants and spectators at the Rio Olympic games were “low and manageable” she was referring to possible exposure to Zika virus. But the other major health concern raised was the quality of the water, particularly for the one to two thousand […]
Spatial intratumoral proliferative heterogeneity in neuroendocrine tumours of the pancreas: assessment and impact
Interactions of neoplastic cells with each other and the microenvironment are complex. The main factors contributing to intratumoral heterogeneity may be reflected in biomarker expression. The aim is to investigate the spatial intratumoral heterogeneity of Ki-67 immunostains in whole sections of pancreatic neuroendocrine neoplasms. The extent and range of heterogeneity has potential as a prognostic […]