Rheumatoid arthritis is a systemic autoimmune disease that is an important socio-economic health problem. Recent evidence about the immunopathogenesis of this disorder might open new perspectives for a more appropriate laboratory approach. In this review, our attention is focused on the clinical relevance and appropriateness of laboratory biomarkers correlated with early diagnosis, prognosis, evolutive aspects […]
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with diverse clinical manifestations. Accurate diagnosis, prediction of disease activity, organ involvement and management remains problematic owing to a lack of reliable biomarkers. This article reviews traditional and a few promising candidate biomarkers in SLE with specific clinical implications. by Dr Anne E. Tebo BackgroundSystemic […]
The spectrum of autoimmune neurological syndromes has expanded substantially in the last fifteen years because of the discovery of novel anti-neuronal autoantibodies. Today’s autoantibody test portfolio includes over 32 different specificities associated with neurological diseases.
Apitope, the drug discovery and development company focused on disease-modifying treatments for patients with autoimmune and allergic diseases, announced today that Bristol University research led by Apitope Founder and CSO, Prof David Wraith, on its treatment approach to autoimmune diseases, such as Multiple Sclerosis (MS), has been published in Nature Communications. The researchers at the […]
The detection of liver/kidney/microsomal antibodies (LKM) is one of the most common analytical procedures performed in the autoimmunity laboratory. Several techniques can be currently adopted that allow the detection of LKM in patient serum, such as ELISA, line immunoassay or indirect immunofluorescence. Far from being outdated, indirect immunofluorescence is the major method used for the […]
Clostridium difficile causes serious life-threatening infections but this organism has a complex pathogenesis that makes differentiating true infection from asymptomatic carriage difficult. There are a number of diagnostic testing approaches that can be used alone or in multi-step algorithms. This review discusses the impact that the type of diagnostic test has on interpretation of clinically […]
Helicobacter cinaedi is a relatively recently identified bacterium, but it is recognized as an increasingly important cause of disease in humans. This article summarizes methods for its detection and identification as well as routes of infection and treatment. by Prof. Yoshiaki Kawamura, Dr Tatsuya Okamoto, Dr Shigemoto Fujii and Prof. Takaaki Akaike What is Helicobacter […]
Kidney disease is one of the most life-threatening complications of diabetes and as the global incidence of diabetes soars, largely due to the dramatic increase in type 2 diabetes (T2DM), there will be a seismic shift in the number of patients in need of treatment through dialysis or transplant. Since up to 40% of diabetic […]
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