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Author Archive for: 3wmedia
Entries by 3wmedia
Clinical response biomarkers in ovarian cancer: current challenges and future directions
Effective screening strategies have not yet been developed for the early detection of ovarian cancer. The serum biomarker CA125, routinely used to aid diagnosis and monitor treatment response, is not informative in all patients. Recent analytical developments have prioritized promising candidate novel biomarkers or multi-biomarker panels for future clinical evaluation. by E. L. Joseph, Dr […]
Unanswered questions about testing for low testosterone in men
Testosterone is a steroid hormone that develops and maintains the primary and secondary sex characteristics in men. In recent years, there has been an explosive increase in prescriptions for testosterone replacement therapy (TRT) in adult men who are thought to have adult-onset hyopgonadism. This increase has been fueled by changing demographics and by increased public […]
Sekisui Diagnostics – Your global partner for over 30 years
Sekisui Diagnostics is a global diagnostics manufacturer focused on the clinical chemistry, coagulation, infectious disease, and enzyme markets. Headquartered in Lexington, MA, we have 10 facilities in 6 countries and over 500 employees worldwide. We are dedicated to delivering differentiated products, instrument systems, and services that support the improvement of patient care worldwide. Formerly Genzyme […]
Carbapenemases: a major threat to healthcare
Bacterial resistance to antibiotics is a major health and economic problem recognized today by national and international policy makers. The Enterobacteriaceae belong to the commensal human gut flora and are frequently the cause of community- and healthcare-associated infections (HAI). Infections with Klebsiella pneumoniae are usually hospital-acquired and occur primarily in patients with impaired host defences […]
Rapid and simultaneous analysis of multiple drugs in hair samples using dynamic multiple reaction monitoring
Hair analysis for forensic diagnostics is gaining popularity in both research and applied settings. Commercially available dynamic multiple reaction monitoring (Dyn-MRM) software applied to hair samples can provide drug-use history for several months. The cost-effective drug test using Dyn-MRM software facilitates analysis of over 200 analytes in a 10-minute chromatographic run. by Professor D. P. […]
Therapeutic drug monitoring of mycophenolic acid and its glucuronide by HPLC/UV
A simple and rapid method for simultaneous determination of mycophenolic acid (MPA) and its glucuronide (MPAG) in plasma using high-performance liquid chromatography (HPLC) with UV detection is described. MPA is an immunosuppressant used in kidney, liver and heart transplantation to prevent organ rejection. Owing to MPA’s narrow therapeutic window and considerable variability within and between […]
New psychoactive substances pose a challenge for drug testing laboratories
New psychoactive substances (NPS) reach the recreational drugs market at a fast pace and are of concern because of potential health risks. In addition to not being legally regulated, NPS escape detection in standard drug tests. Drug testing laboratories, therefore, must adapt their analytical methods to also cover these new substances. For screening and confirmation […]
Monitoring methotrexate polyglutamate levels in inflammatory bowel disease: where do we stand?
Methotrexate is an established treatment for inflammatory bowel disease, however it is commonly only used as second-line therapy due to concerns over side effects. This article reviews the evidence for using methotrexate polyglutamate levels in the management of rheumatoid arthritis and psoriasis in addition to inflammatory bowel disease with a view to optimizing treatment and […]
Determination of methylphenidate and ritalinic acid in serum and saliva of patients with ADHD
by Sophie Studer, Hans-Willi Clement, Christian Fleischhaker, Eberhard Schulz Attention deficit hyperactivity disorder (ADHD)What do fidgets and Johnny Head-in-the-Clouds (a fictional character from a German tale) have in common with Alexander the Great, Winston Churchill or Benjamin Franklin? For all of these, a diagnosis of ADHD would be made today [1]. The first indications of […]